α1,3-Fucoslytransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX

Mika Kaneko; Takashi Kudo; Hiroko Iwasaki; Yuzuru Ikehara; Shoko Nishihara; Satoshi Nakagawa; Katsutoshi Sasaki; Takashi Shiina; Hidetoshi Inoko; Naruya Saitou; Hisashi Narimatsu

doi:10.1016/S0014-5793(99)00640-7

α1,3-Fucoslytransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX

Mika Kaneko, Takashi Kudo, Hiroko Iwasaki, Yuzuru Ikehara, Shoko Nishihara, Satoshi Nakagawa, Katsutoshi Sasaki, Takashi Shiina, Hidetoshi Inoko, Naruya Saitou, Hisashi Narimatsu

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

105 Citations (Scopus)

Abstract

The amino acid sequence of Fuc-TIX is very highly conserved between mouse and human. The number of non-synonymous nucleotide substitutions of the Fuc-TIX gene between human and mouse was strikingly low, and almost equivalent to that of the α-actin gene. This indicates that Fuc-TIX is under a strong selective pressure of preservation during evolution. The human Fuc-TIX (hFuc-TIX) showed a unique characteristics, i.e. hFuc-TIX was not activated by Mn²⁺ and Co²⁺, whereas hFuc-TIV and hFuc-TVI were activated by the cations. The hFuc-TIX transcripts were abundantly expressed in brain and stomach, and interestingly were detected in spleen and peripheral blood leukocytes. Copyright (C) 1999 Federation of European Biochemical Societies.

Original language	English
Pages (from-to)	237-242
Number of pages	6
Journal	FEBS Letters
Volume	452
Issue number	3
DOIs	https://doi.org/10.1016/S0014-5793(99)00640-7
Publication status	Published - 1999 Jun 11

Keywords

CD15
Fucosyltransferase
Glycosyltransferase
Lewis x
SSEA-1
α1,3-Fucosyltransferase

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10.1016/S0014-5793(99)00640-7

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Kaneko, M., Kudo, T., Iwasaki, H., Ikehara, Y., Nishihara, S., Nakagawa, S., Sasaki, K., Shiina, T., Inoko, H., Saitou, N., & Narimatsu, H. (1999). α1,3-Fucoslytransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX. FEBS Letters, 452(3), 237-242. https://doi.org/10.1016/S0014-5793(99)00640-7

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title = "α1,3-Fucoslytransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX",

abstract = "The amino acid sequence of Fuc-TIX is very highly conserved between mouse and human. The number of non-synonymous nucleotide substitutions of the Fuc-TIX gene between human and mouse was strikingly low, and almost equivalent to that of the α-actin gene. This indicates that Fuc-TIX is under a strong selective pressure of preservation during evolution. The human Fuc-TIX (hFuc-TIX) showed a unique characteristics, i.e. hFuc-TIX was not activated by Mn2+ and Co2+, whereas hFuc-TIV and hFuc-TVI were activated by the cations. The hFuc-TIX transcripts were abundantly expressed in brain and stomach, and interestingly were detected in spleen and peripheral blood leukocytes. Copyright (C) 1999 Federation of European Biochemical Societies.",

keywords = "CD15, Fucosyltransferase, Glycosyltransferase, Lewis x, SSEA-1, α1,3-Fucosyltransferase",

author = "Mika Kaneko and Takashi Kudo and Hiroko Iwasaki and Yuzuru Ikehara and Shoko Nishihara and Satoshi Nakagawa and Katsutoshi Sasaki and Takashi Shiina and Hidetoshi Inoko and Naruya Saitou and Hisashi Narimatsu",

note = "Funding Information: This work was supported in part by a Grant-in-Aid for Scientific Research on Priority Areas, No. 10178104, from the Ministry of Education, Science, and Culture of Japan.",

year = "1999",

month = jun,

day = "11",

doi = "10.1016/S0014-5793(99)00640-7",

language = "English",

volume = "452",

pages = "237--242",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "Wiley-Blackwell",

number = "3",

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Kaneko, M, Kudo, T, Iwasaki, H, Ikehara, Y, Nishihara, S, Nakagawa, S, Sasaki, K, Shiina, T, Inoko, H, Saitou, N & Narimatsu, H 1999, 'α1,3-Fucoslytransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX', FEBS Letters, vol. 452, no. 3, pp. 237-242. https://doi.org/10.1016/S0014-5793(99)00640-7

TY - JOUR

T1 - α1,3-Fucoslytransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX

AU - Kaneko, Mika

AU - Kudo, Takashi

AU - Iwasaki, Hiroko

AU - Ikehara, Yuzuru

AU - Nishihara, Shoko

AU - Nakagawa, Satoshi

AU - Sasaki, Katsutoshi

AU - Shiina, Takashi

AU - Inoko, Hidetoshi

AU - Saitou, Naruya

AU - Narimatsu, Hisashi

N1 - Funding Information: This work was supported in part by a Grant-in-Aid for Scientific Research on Priority Areas, No. 10178104, from the Ministry of Education, Science, and Culture of Japan.

PY - 1999/6/11

Y1 - 1999/6/11

N2 - The amino acid sequence of Fuc-TIX is very highly conserved between mouse and human. The number of non-synonymous nucleotide substitutions of the Fuc-TIX gene between human and mouse was strikingly low, and almost equivalent to that of the α-actin gene. This indicates that Fuc-TIX is under a strong selective pressure of preservation during evolution. The human Fuc-TIX (hFuc-TIX) showed a unique characteristics, i.e. hFuc-TIX was not activated by Mn2+ and Co2+, whereas hFuc-TIV and hFuc-TVI were activated by the cations. The hFuc-TIX transcripts were abundantly expressed in brain and stomach, and interestingly were detected in spleen and peripheral blood leukocytes. Copyright (C) 1999 Federation of European Biochemical Societies.

AB - The amino acid sequence of Fuc-TIX is very highly conserved between mouse and human. The number of non-synonymous nucleotide substitutions of the Fuc-TIX gene between human and mouse was strikingly low, and almost equivalent to that of the α-actin gene. This indicates that Fuc-TIX is under a strong selective pressure of preservation during evolution. The human Fuc-TIX (hFuc-TIX) showed a unique characteristics, i.e. hFuc-TIX was not activated by Mn2+ and Co2+, whereas hFuc-TIV and hFuc-TVI were activated by the cations. The hFuc-TIX transcripts were abundantly expressed in brain and stomach, and interestingly were detected in spleen and peripheral blood leukocytes. Copyright (C) 1999 Federation of European Biochemical Societies.

KW - CD15

KW - Fucosyltransferase

KW - Glycosyltransferase

KW - Lewis x

KW - SSEA-1

KW - α1,3-Fucosyltransferase

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DO - 10.1016/S0014-5793(99)00640-7

M3 - Article

C2 - 10386598

AN - SCOPUS:0032586973

SN - 0014-5793

VL - 452

SP - 237

EP - 242

JO - FEBS Letters

JF - FEBS Letters

IS - 3

ER -

α1,3-Fucoslytransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX

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Keywords

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