TY - JOUR
T1 - β-lactolin increases cerebral blood flow in dorsolateral prefrontal cortex in healthy adults
T2 - A randomized controlled trial
AU - Ano, Yasuhisa
AU - Kobayashi, Keiko
AU - Hanyuda, Mamoru
AU - Kawashima, Ryuta
N1 - Funding Information:
K.K. and Y.A. are employees of Kirin Holdings Company, Ltd., the study sponsor. All authors have declared that they have no other disclosures. This study was funded by the Kirin Holdings Company, Ltd. The funder designed this study and supplied the test tablets and placebo. The funder, however, had no role in data collection or analysis. The manuscript was prepared by members of the funder and the funder decided to publish the results.
Publisher Copyright:
© 2020 Ano et al.
PY - 2020/9/30
Y1 - 2020/9/30
N2 - The number of elderly individuals with age-related cognitive decline or dementia is rapidly increasing. Dairy product consumption, including β-lactolin, is beneficial for their cognitive function. The underlying mechanism of β-lactolin's effects on human brain activity is yet to be investigated. We examined the β-lactolin effects on human cerebral blood flow (CBF) using near-infrared spectroscopy (NIRS) in a placebo-controlled randomized double-blind study, which reported according to the CONSORT guidelines. Fifty healthy participants (aged 45-60 years) were randomly allocated into the β-lactolin or the placebo group (n = 25 each) and supplemented for 6 weeks. During the 6th week, oxy-hemoglobin during the working memory tasks was measured using 34-channels (CHs) NIRS. The changes of oxy-hemoglobin, which represents the CBF, in CH 23 located at the left dorsolateral prefrontal cortex (DLPFC) during the spatial working memory task showed higher statistical significance (false discovery rate (q) = 0.045) in the β-lactolin than in the placebo group. The oxy-Hb changes in CH23 have a co-relationship with the working memory task reaction time. This clinical trial showed an increase in the CBF in the left DLPFC area during the 6-week β-lactolin supplementation. This study contributes to elucidating the underlying mechanisms of β-lactolin on cognitive performance.
AB - The number of elderly individuals with age-related cognitive decline or dementia is rapidly increasing. Dairy product consumption, including β-lactolin, is beneficial for their cognitive function. The underlying mechanism of β-lactolin's effects on human brain activity is yet to be investigated. We examined the β-lactolin effects on human cerebral blood flow (CBF) using near-infrared spectroscopy (NIRS) in a placebo-controlled randomized double-blind study, which reported according to the CONSORT guidelines. Fifty healthy participants (aged 45-60 years) were randomly allocated into the β-lactolin or the placebo group (n = 25 each) and supplemented for 6 weeks. During the 6th week, oxy-hemoglobin during the working memory tasks was measured using 34-channels (CHs) NIRS. The changes of oxy-hemoglobin, which represents the CBF, in CH 23 located at the left dorsolateral prefrontal cortex (DLPFC) during the spatial working memory task showed higher statistical significance (false discovery rate (q) = 0.045) in the β-lactolin than in the placebo group. The oxy-Hb changes in CH23 have a co-relationship with the working memory task reaction time. This clinical trial showed an increase in the CBF in the left DLPFC area during the 6-week β-lactolin supplementation. This study contributes to elucidating the underlying mechanisms of β-lactolin on cognitive performance.
KW - Cerebral blood flow
KW - Dorsolateral prefrontal cortex
KW - Near-infrared spectroscopy (NIRS)
KW - ß-lactolin
KW - ß-lactopeptide
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UR - http://www.scopus.com/inward/citedby.url?scp=85091874947&partnerID=8YFLogxK
U2 - 10.18632/aging.103951
DO - 10.18632/aging.103951
M3 - Article
C2 - 32989176
AN - SCOPUS:85091874947
SN - 1945-4589
VL - 12
SP - 18660
EP - 18675
JO - Aging
JF - Aging
IS - 18
ER -
