γ-Carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity

Kumiko Sako; Hiroshi Aoyama; Shinichi Sato; Yuichi Hashimoto; Masanori Baba

doi:10.1016/j.bmc.2008.01.052

γ-Carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity

Kumiko Sako, Hiroshi Aoyama, Shinichi Sato, Yuichi Hashimoto, Masanori Baba

FRIS - Core Interdisciplinary Research Section

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

Based on anti-viral screening of our heteroaromatics derived from thalidomide, the γ-carboline skeleton has been identified as a superior scaffold structure for compounds with potent anti-bovine viral diarrhea virus (BVDV) activity. Structural development studies led to a potent anti-viral agent, SK5M (5-methyl-γ-carboline), with the EC₅₀ of 0.26 μM.

Original language	English
Pages (from-to)	3780-3790
Number of pages	11
Journal	Bioorganic and Medicinal Chemistry
Volume	16
Issue number	7
DOIs	https://doi.org/10.1016/j.bmc.2008.01.052
Publication status	Published - 2008 Apr 1

Keywords

γ-Carboline
Anti-BVDV agents
Thalidomide

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmc.2008.01.052

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abstract = "Based on anti-viral screening of our heteroaromatics derived from thalidomide, the γ-carboline skeleton has been identified as a superior scaffold structure for compounds with potent anti-bovine viral diarrhea virus (BVDV) activity. Structural development studies led to a potent anti-viral agent, SK5M (5-methyl-γ-carboline), with the EC50 of 0.26 μM.",

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AU - Sako, Kumiko

AU - Aoyama, Hiroshi

AU - Sato, Shinichi

AU - Hashimoto, Yuichi

AU - Baba, Masanori

PY - 2008/4/1

Y1 - 2008/4/1

N2 - Based on anti-viral screening of our heteroaromatics derived from thalidomide, the γ-carboline skeleton has been identified as a superior scaffold structure for compounds with potent anti-bovine viral diarrhea virus (BVDV) activity. Structural development studies led to a potent anti-viral agent, SK5M (5-methyl-γ-carboline), with the EC50 of 0.26 μM.

AB - Based on anti-viral screening of our heteroaromatics derived from thalidomide, the γ-carboline skeleton has been identified as a superior scaffold structure for compounds with potent anti-bovine viral diarrhea virus (BVDV) activity. Structural development studies led to a potent anti-viral agent, SK5M (5-methyl-γ-carboline), with the EC50 of 0.26 μM.

KW - γ-Carboline

KW - Anti-BVDV agents

KW - Thalidomide

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γ-Carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity

Abstract

Keywords

UN SDGs

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