@article{cf481d40fd3945119be39b0b0bfdaccc,
title = "1-Methyl-4-aryl-urazole (MAUra) labels tyrosine in proximity to ruthenium photocatalysts",
abstract = "We designed and synthesised peptides conjugated with proline linkers and ruthenium photocatalysts. These peptides were used as substrates to evaluate the photocatalyst-proximity dependences of candidates for tyrosine labelling reagents. The 1-methyl-4-aryl-urazole (MAUra) structure was found to be a novel tyrosyl radical trapping agent to label tyrosine residues effectively under the conditions where the ruthenium photocatalyst and tyrosine were in close proximity. Using a ruthenium photocatalyst conjugated to a carbonic anhydrase ligand, the target protein in a complex protein mixture was labelled with remarkable target selectivity by azide- or desthiobiotin-conjugated MAUra derivatives.",
author = "Shinichi Sato and Kensuke Hatano and Michihiko Tsushima and Hiroyuki Nakamura",
note = "Funding Information: This work was partially supported by Grants-in-Aid for {\textquoteleft}Grant-in-Aid for Young Scientists (A) (15H05490 to S. Sato){\textquoteright}, {\textquoteleft}Homeostatic Regulation by Various Types of Cell Death (15H01372 to S. Sato){\textquoteright} and {\textquoteleft}Chemistry for Multimolecular Crowding Biosystems (18H04542 to H. Nakamura){\textquoteright} from MEXT, Japan. We would like to thank Dr Y. Tanaka for the discussion on cyclic voltammetry (Laboratory for Chemistry and Life Science, Tokyo Institute of Technology). Publisher Copyright: {\textcopyright} 2018 The Royal Society of Chemistry.",
year = "2018",
doi = "10.1039/c8cc02891e",
language = "English",
volume = "54",
pages = "5871--5874",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "46",
}