12T061C, a new Julichrome family radical scavenger from Streptomyces species

Toshikazu Komoda; Naoko Saeki; Yoshitaka Koseki; Hiromasa Kiyota

doi:10.1515/hc-2014-0126

12T061C, a new Julichrome family radical scavenger from Streptomyces species

Toshikazu Komoda, Naoko Saeki, Yoshitaka Koseki, Hiromasa Kiyota

Materials-Measurement Hybrid Research Center

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The new radical scavenger 12T061C (C₂₀H₂₂O₇) has been identified from a culture of Streptomyces species. Spectroscopic elucidation showed that this compound is a new Julichrome family compound. 12T061C shows a potent radical-scavenging activity with an ED₅₀ of 18 μm that is similar to those of the known antioxidant compounds α-tocopherol (ED₅₀ 16 μm) and quercetin (ED₅₀ 3 μm).

Original language	English
Pages (from-to)	271-274
Number of pages	4
Journal	Heterocyclic Communications
Volume	20
Issue number	5
DOIs	https://doi.org/10.1515/hc-2014-0126
Publication status	Published - 2014 Oct 1

Keywords

2 2-diphenyl-1-picrylhydrazyl (DPPH)
Julichrome
Streptomyces species
radical scavenger

ASJC Scopus subject areas

Organic Chemistry

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title = "12T061C, a new Julichrome family radical scavenger from Streptomyces species",

abstract = "The new radical scavenger 12T061C (C20H22O7) has been identified from a culture of Streptomyces species. Spectroscopic elucidation showed that this compound is a new Julichrome family compound. 12T061C shows a potent radical-scavenging activity with an ED50 of 18 μm that is similar to those of the known antioxidant compounds α-tocopherol (ED50 16 μm) and quercetin (ED50 3 μm).",

keywords = "2 2-diphenyl-1-picrylhydrazyl (DPPH), Julichrome, Streptomyces species, radical scavenger",

author = "Toshikazu Komoda and Naoko Saeki and Yoshitaka Koseki and Hiromasa Kiyota",

note = "Publisher Copyright: {\textcopyright} 2014 by De Gruyter 2014.",

year = "2014",

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doi = "10.1515/hc-2014-0126",

language = "English",

volume = "20",

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T1 - 12T061C, a new Julichrome family radical scavenger from Streptomyces species

AU - Komoda, Toshikazu

AU - Saeki, Naoko

AU - Koseki, Yoshitaka

AU - Kiyota, Hiromasa

PY - 2014/10/1

Y1 - 2014/10/1

N2 - The new radical scavenger 12T061C (C20H22O7) has been identified from a culture of Streptomyces species. Spectroscopic elucidation showed that this compound is a new Julichrome family compound. 12T061C shows a potent radical-scavenging activity with an ED50 of 18 μm that is similar to those of the known antioxidant compounds α-tocopherol (ED50 16 μm) and quercetin (ED50 3 μm).

AB - The new radical scavenger 12T061C (C20H22O7) has been identified from a culture of Streptomyces species. Spectroscopic elucidation showed that this compound is a new Julichrome family compound. 12T061C shows a potent radical-scavenging activity with an ED50 of 18 μm that is similar to those of the known antioxidant compounds α-tocopherol (ED50 16 μm) and quercetin (ED50 3 μm).

KW - 2 2-diphenyl-1-picrylhydrazyl (DPPH)

KW - Julichrome

KW - Streptomyces species

KW - radical scavenger

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VL - 20

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JO - Heterocyclic Communications

JF - Heterocyclic Communications

IS - 5

ER -

12T061C, a new Julichrome family radical scavenger from Streptomyces species

Abstract

Keywords

ASJC Scopus subject areas

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