2-Amino-6-vinyl purine as a tool for post synthetic conjugation of DNA with radio-, spin-, fluorescence labels and peptides.

Md Monsur Ali; Fumi Nagatsugi; Fumihiko Yamamoto; Minoru Maeda; Shigeki Sasaki

2-Amino-6-vinyl purine as a tool for post synthetic conjugation of DNA with radio-, spin-, fluorescence labels and peptides.

Md Monsur Ali, Fumi Nagatsugi, Fumihiko Yamamoto, Minoru Maeda, Shigeki Sasaki

IMRAM - Division of Organic- and Biomaterials Research

Kyushu University

Research output: Contribution to journal › Article › peer-review

Abstract

We have previously demonstrated that 2-amino-6-vinylpurine is an efficient cross-linking agent with high selectivity towards cytidine. In this study, we applied this nucleobase analog to versatile conjugation of oligodeoxynucleotides with radio-, spin-, fluorescence- and peptide labels. The oligodeoxynucleotides incorporating 2-amino-6-vinylpurine nucleoside were reacted with amino- bearing nucleophies in an excess amount to give the corresponding conjugates in good yield.

Original language	English
Pages (from-to)	149-150
Number of pages	2
Journal	Nucleic acids research. Supplement (2001)
Issue number	2
Publication status	Published - 2002

Cite this

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abstract = "We have previously demonstrated that 2-amino-6-vinylpurine is an efficient cross-linking agent with high selectivity towards cytidine. In this study, we applied this nucleobase analog to versatile conjugation of oligodeoxynucleotides with radio-, spin-, fluorescence- and peptide labels. The oligodeoxynucleotides incorporating 2-amino-6-vinylpurine nucleoside were reacted with amino- bearing nucleophies in an excess amount to give the corresponding conjugates in good yield.",

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AU - Maeda, Minoru

AU - Sasaki, Shigeki

PY - 2002

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AB - We have previously demonstrated that 2-amino-6-vinylpurine is an efficient cross-linking agent with high selectivity towards cytidine. In this study, we applied this nucleobase analog to versatile conjugation of oligodeoxynucleotides with radio-, spin-, fluorescence- and peptide labels. The oligodeoxynucleotides incorporating 2-amino-6-vinylpurine nucleoside were reacted with amino- bearing nucleophies in an excess amount to give the corresponding conjugates in good yield.

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ER -

2-Amino-6-vinyl purine as a tool for post synthetic conjugation of DNA with radio-, spin-, fluorescence labels and peptides.

Abstract

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