2′-deoxy-4′-C-ethynyl-2-fluoroadenosine: A nucleoside reverse transcriptase inhibitor with highly potent activity against wide spectrum of HIV-1 strains, favorable toxic profiles, and stability in plasma

Hiroshi Ohrui; Satoru Kohgo; Hiroyuki Hayakawa; Eiichi Kodama; Masao Matsuoka; Tomohiro Nakata; Hiroaki Mitsuya

doi:10.1080/15257770701545218

2′-deoxy-4′-C-ethynyl-2-fluoroadenosine: A nucleoside reverse transcriptase inhibitor with highly potent activity against wide spectrum of HIV-1 strains, favorable toxic profiles, and stability in plasma

Hiroshi Ohrui, Satoru Kohgo, Hiroyuki Hayakawa, Eiichi Kodama, Masao Matsuoka, Tomohiro Nakata, Hiroaki Mitsuya

IRIDeS - Disaster Medical Science Division

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Working hypotheses to solve the critical problems of the existing highly active anti-retroviral therapy were proposed. The study based on the hypotheses proved the validity of the hypotheses and resulted in the development of 2′-deoxy-4′-C-ethynyl-2-fluoroadenosine, a nucleoside reverse transcriptase inhibitor, with highly potent activity against all HIV-1, very favorable toxic profiles, and stability in plasma. The nucleoside will prevent or delay the emergence of drug-resistant HIV-1 variants and be an ideal therapeutic agent for both HIV-1 and HBV infections.

Original language	English
Pages (from-to)	1543-1546
Number of pages	4
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	26
Issue number	10-12
DOIs	https://doi.org/10.1080/15257770701545218
Publication status	Published - 2007 Oct

Keywords

2′-Deoxy-4′-C-ethynyl nucleoside
2,′3′- dideoxynucleoside
Drug resistant HIV
HAART
Nucleoside reverse transcriptase inhibitors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/15257770701545218

Fingerprint

Dive into the research topics of '2′-deoxy-4′-C-ethynyl-2-fluoroadenosine: A nucleoside reverse transcriptase inhibitor with highly potent activity against wide spectrum of HIV-1 strains, favorable toxic profiles, and stability in plasma'. Together they form a unique fingerprint.

Cite this

Ohrui, H., Kohgo, S., Hayakawa, H., Kodama, E., Matsuoka, M., Nakata, T., & Mitsuya, H. (2007). 2′-deoxy-4′-C-ethynyl-2-fluoroadenosine: A nucleoside reverse transcriptase inhibitor with highly potent activity against wide spectrum of HIV-1 strains, favorable toxic profiles, and stability in plasma. Nucleosides, Nucleotides and Nucleic Acids, 26(10-12), 1543-1546. https://doi.org/10.1080/15257770701545218

@article{e9e38a83c46941ae95d99dc9009eab34,

title = "2′-deoxy-4′-C-ethynyl-2-fluoroadenosine: A nucleoside reverse transcriptase inhibitor with highly potent activity against wide spectrum of HIV-1 strains, favorable toxic profiles, and stability in plasma",

abstract = "Working hypotheses to solve the critical problems of the existing highly active anti-retroviral therapy were proposed. The study based on the hypotheses proved the validity of the hypotheses and resulted in the development of 2′-deoxy-4′-C-ethynyl-2-fluoroadenosine, a nucleoside reverse transcriptase inhibitor, with highly potent activity against all HIV-1, very favorable toxic profiles, and stability in plasma. The nucleoside will prevent or delay the emergence of drug-resistant HIV-1 variants and be an ideal therapeutic agent for both HIV-1 and HBV infections.",

keywords = "2′-Deoxy-4′-C-ethynyl nucleoside, 2,′3′- dideoxynucleoside, Drug resistant HIV, HAART, Nucleoside reverse transcriptase inhibitors",

author = "Hiroshi Ohrui and Satoru Kohgo and Hiroyuki Hayakawa and Eiichi Kodama and Masao Matsuoka and Tomohiro Nakata and Hiroaki Mitsuya",

year = "2007",

month = oct,

doi = "10.1080/15257770701545218",

language = "English",

volume = "26",

pages = "1543--1546",

journal = "Nucleosides, Nucleotides and Nucleic Acids",

issn = "1525-7770",

publisher = "Taylor and Francis Ltd.",

number = "10-12",

}

Ohrui, H, Kohgo, S, Hayakawa, H, Kodama, E, Matsuoka, M, Nakata, T & Mitsuya, H 2007, '2′-deoxy-4′-C-ethynyl-2-fluoroadenosine: A nucleoside reverse transcriptase inhibitor with highly potent activity against wide spectrum of HIV-1 strains, favorable toxic profiles, and stability in plasma', Nucleosides, Nucleotides and Nucleic Acids, vol. 26, no. 10-12, pp. 1543-1546. https://doi.org/10.1080/15257770701545218

2′-deoxy-4′-C-ethynyl-2-fluoroadenosine: A nucleoside reverse transcriptase inhibitor with highly potent activity against wide spectrum of HIV-1 strains, favorable toxic profiles, and stability in plasma. / Ohrui, Hiroshi; Kohgo, Satoru; Hayakawa, Hiroyuki et al.
In: Nucleosides, Nucleotides and Nucleic Acids, Vol. 26, No. 10-12, 10.2007, p. 1543-1546.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - 2′-deoxy-4′-C-ethynyl-2-fluoroadenosine

T2 - A nucleoside reverse transcriptase inhibitor with highly potent activity against wide spectrum of HIV-1 strains, favorable toxic profiles, and stability in plasma

AU - Ohrui, Hiroshi

AU - Kohgo, Satoru

AU - Hayakawa, Hiroyuki

AU - Kodama, Eiichi

AU - Matsuoka, Masao

AU - Nakata, Tomohiro

AU - Mitsuya, Hiroaki

PY - 2007/10

Y1 - 2007/10

N2 - Working hypotheses to solve the critical problems of the existing highly active anti-retroviral therapy were proposed. The study based on the hypotheses proved the validity of the hypotheses and resulted in the development of 2′-deoxy-4′-C-ethynyl-2-fluoroadenosine, a nucleoside reverse transcriptase inhibitor, with highly potent activity against all HIV-1, very favorable toxic profiles, and stability in plasma. The nucleoside will prevent or delay the emergence of drug-resistant HIV-1 variants and be an ideal therapeutic agent for both HIV-1 and HBV infections.

AB - Working hypotheses to solve the critical problems of the existing highly active anti-retroviral therapy were proposed. The study based on the hypotheses proved the validity of the hypotheses and resulted in the development of 2′-deoxy-4′-C-ethynyl-2-fluoroadenosine, a nucleoside reverse transcriptase inhibitor, with highly potent activity against all HIV-1, very favorable toxic profiles, and stability in plasma. The nucleoside will prevent or delay the emergence of drug-resistant HIV-1 variants and be an ideal therapeutic agent for both HIV-1 and HBV infections.

KW - 2′-Deoxy-4′-C-ethynyl nucleoside

KW - 2,′3′- dideoxynucleoside

KW - Drug resistant HIV

KW - HAART

KW - Nucleoside reverse transcriptase inhibitors

UR - http://www.scopus.com/inward/record.url?scp=36949009453&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36949009453&partnerID=8YFLogxK

U2 - 10.1080/15257770701545218

DO - 10.1080/15257770701545218

M3 - Article

C2 - 18066823

AN - SCOPUS:36949009453

SN - 1525-7770

VL - 26

SP - 1543

EP - 1546

JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

IS - 10-12

ER -

Ohrui H, Kohgo S, Hayakawa H, Kodama E, Matsuoka M, Nakata T et al. 2′-deoxy-4′-C-ethynyl-2-fluoroadenosine: A nucleoside reverse transcriptase inhibitor with highly potent activity against wide spectrum of HIV-1 strains, favorable toxic profiles, and stability in plasma. Nucleosides, Nucleotides and Nucleic Acids. 2007 Oct;26(10-12):1543-1546. doi: 10.1080/15257770701545218

2′-deoxy-4′-C-ethynyl-2-fluoroadenosine: A nucleoside reverse transcriptase inhibitor with highly potent activity against wide spectrum of HIV-1 strains, favorable toxic profiles, and stability in plasma

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this