2,4-Diamino-6,7-dimethylpteridine as a fluorescent ligand for binding and sensing an orphan cytosine in RNA duplexes

Yusuke Sato; Yu Toriyabe; Seiichi Nishizawa; Norio Teramae

doi:10.1039/c3cc46085a

2,4-Diamino-6,7-dimethylpteridine as a fluorescent ligand for binding and sensing an orphan cytosine in RNA duplexes

Yusuke Sato, Yu Toriyabe, Seiichi Nishizawa, Norio Teramae

SCI - Chemistry

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

We report on a new fluorescent ligand, 2,4-diamino-6,7-dimethylpteridine, that can strongly and selectively bind to an orphan cytosine opposite an abasic site in RNA duplexes. We describe a significant effect of the substituents attached to the pteridine ring on the binding behavior in comparison with a structurally-similar pteridine derivative.

Original language	English
Pages (from-to)	9983-9985
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	85
DOIs	https://doi.org/10.1039/c3cc46085a
Publication status	Published - 2013 Oct

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/c3cc46085a

Cite this

@article{9bd9454b1fde45518c167c6ca9fb6e76,

title = "2,4-Diamino-6,7-dimethylpteridine as a fluorescent ligand for binding and sensing an orphan cytosine in RNA duplexes",

abstract = "We report on a new fluorescent ligand, 2,4-diamino-6,7-dimethylpteridine, that can strongly and selectively bind to an orphan cytosine opposite an abasic site in RNA duplexes. We describe a significant effect of the substituents attached to the pteridine ring on the binding behavior in comparison with a structurally-similar pteridine derivative.",

author = "Yusuke Sato and Yu Toriyabe and Seiichi Nishizawa and Norio Teramae",

year = "2013",

month = oct,

doi = "10.1039/c3cc46085a",

language = "English",

volume = "49",

pages = "9983--9985",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "85",

}

TY - JOUR

T1 - 2,4-Diamino-6,7-dimethylpteridine as a fluorescent ligand for binding and sensing an orphan cytosine in RNA duplexes

AU - Sato, Yusuke

AU - Toriyabe, Yu

AU - Nishizawa, Seiichi

AU - Teramae, Norio

PY - 2013/10

Y1 - 2013/10

N2 - We report on a new fluorescent ligand, 2,4-diamino-6,7-dimethylpteridine, that can strongly and selectively bind to an orphan cytosine opposite an abasic site in RNA duplexes. We describe a significant effect of the substituents attached to the pteridine ring on the binding behavior in comparison with a structurally-similar pteridine derivative.

AB - We report on a new fluorescent ligand, 2,4-diamino-6,7-dimethylpteridine, that can strongly and selectively bind to an orphan cytosine opposite an abasic site in RNA duplexes. We describe a significant effect of the substituents attached to the pteridine ring on the binding behavior in comparison with a structurally-similar pteridine derivative.

UR - http://www.scopus.com/inward/record.url?scp=84885168935&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885168935&partnerID=8YFLogxK

U2 - 10.1039/c3cc46085a

DO - 10.1039/c3cc46085a

M3 - Article

C2 - 24042469

AN - SCOPUS:84885168935

SN - 1359-7345

VL - 49

SP - 9983

EP - 9985

JO - Chemical Communications

JF - Chemical Communications

IS - 85

ER -

2,4-Diamino-6,7-dimethylpteridine as a fluorescent ligand for binding and sensing an orphan cytosine in RNA duplexes

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this