@article{15d68d5428b047d4b0e05f252f2afaab,
title = "3D electrochemical and ion current imaging using scanning electrochemical-scanning ion conductance microscopy",
abstract = "Local cell-membrane permeability and ionic strength are important factors for maintaining the functions of cells. Here, we measured the spatial electrochemical and ion concentration profile near the sample surface with nanoscale resolution using scanning electrochemical microscopy (SECM) combined with scanning ion-conductance microscopy (SICM). The ion current feedback system is an effective way to control probe-sample distance without contact and monitor the kinetic effect of mediator regeneration and the chemical concentration profile. For demonstrating 3D electrochemical and ion concentration mapping, we evaluated the reaction rate of electrochemical mediator regeneration on an unbiased conductor and visualized inhomogeneous permeability and the ion concentration 3D profile on a single fixed adipocyte cell surface.",
author = "Yasufumi Takahashi and Hiroki Ida and Yoshiharu Matsumae and Hirokazu Komaki and Yuanshu Zhou and Akichika Kumatani and Makoto Kanzaki and Hitoshi Shiku and Tomokazu Matsue",
note = "Funding Information: This work was supported by Development of Systems and Technology for Advanced Measurement and Analysis from AMED (The Japan Agency for Medical Research and Development)-SENTAN, and ALCA and PREST from the Japan Science and Technology Agency (JST), a Grant-in-Aid for Scientific Research (A) (16H02280), a Grant-in-Aid for Scientific Research (B) (15H03542), a Grant-in-Aid for Young Scientists (A) (15H05422 and 16H06042), a Grant-in-Aid for Exploratory Research (15K13263), and Grant-in-Aid for Scientific Research on Innovative Areas (16H00885) from the Japan Society for the Promotion of Science (JSPS) and the Nakatani Foundation and the Asahi Glass Foundation are all thankfully acknowledged for financial support. Publisher Copyright: {\textcopyright} 2017 the Owner Societies.",
year = "2017",
doi = "10.1039/c7cp05157c",
language = "English",
volume = "19",
pages = "26728--26733",
journal = "Physical Chemistry Chemical Physics",
issn = "1463-9076",
publisher = "Royal Society of Chemistry",
number = "39",
}