@inproceedings{c6ee66fccedb4367ba73319349a07246,
title = "5-ALA induced PpIX fluorescence guided surgery of gliomas: Comparison of expert and machine learning based models",
abstract = "Gliomas are diffuse brain tumors still hardly curable due to the difficulties to identify margins. 5-ALA induced PpIX fluorescence measurements enable to gain in sensitivity but are still limited to discriminate margin from healthy tissue. In this fluorescence spectroscopic study, we compare an expert-based model assuming that two states of PpIX contribute to total fluorescence and machine learning-based models. We show that machine learning retrieves the main features identified by the expert approach. We also show that machine learning approach slightly overpasses expert-based model for the identification of healthy tissues. These results might help to improve fluorescence-guided resection of gliomas by discriminating healthy tissues from tumor margins.",
keywords = "5-ALA, Fluorescence spectroscopy, Glioma, Human brain; machine learning; classification, Interventional imaging, Neurosurgery, Protoporphyrin IX",
author = "P. Leclerc and L. Alston and L. Mahieu-Williame and C. Ray and M. H{\'e}bert and P. Kantapareddy and C. Frindel and Brevet, {P. F.} and D. Meyronet and J. Guyotat and D. Rousseau and B. Montcel",
note = "Funding Information: LABEX PRIMES (ANR-11-LABX-0063) and LABEX iMUST (ANR-10-LABX-0064) of Universit{\'e} de Lyon, within the program “Investissements d{\textquoteright}Avenir” (ANR-11-IDEX-0007) operated by the French National Research Agency (ANR); Canc{\'e}rop{\^o}le Lyon Auvergne Rh{\^o}ne Alpes (CLARA) within the program “OncoStarter”; Infrastructures d{\textquoteright}Avenir en Biologie Sant{\'e} (ANR-11-INBS-000), within the program {"}Investissements d{\textquoteright}Avenir{"} operated by the French National Research Agency (ANR). French National Research Agency (ANR), under Grant ANR-17-CE19-0003 (ARMONI Project). The authors thank the PILoT facility for the support provided on signal acquisition. Publisher Copyright: {\textcopyright} COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.; Clinical and Translational Neurophotonics 2020 ; Conference date: 01-01-2020",
year = "2019",
doi = "10.1117/12.2546670",
language = "English",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Madsen, {Steen J.} and Yang, {Victor X. D.} and Thakor, {Nitish V.}",
booktitle = "Clinical and Translational Neurophotonics 2020",
address = "United States",
}
