TY - JOUR
T1 - 6,7-Dimethyllumazine as a potential ligand for selective recognition of adenine opposite an abasic site in DNA duplexes
AU - Ye, Zhiqiang
AU - Rajendar, Burki
AU - Qing, Dai
AU - Nishizawa, Seiichi
AU - Teramae, Norio
PY - 2008
Y1 - 2008
N2 - 6,7-Dimethyllumazine more selectively binds to adenine (A) base opposite the abasic site in DNA duplexes (5′-TCC AGX GCA AC-3′/3′-AGG TCN CGT TG-5′, X = AP site (Spacer C3), N = A, T, C and G) than the other three nucleobases with a dissociation constant Kd of ca. 1.0 μM; substituted methyl groups enhance the binding affinity to A and the selectivity for A over T, compared to the parent molecule, lumazine.
AB - 6,7-Dimethyllumazine more selectively binds to adenine (A) base opposite the abasic site in DNA duplexes (5′-TCC AGX GCA AC-3′/3′-AGG TCN CGT TG-5′, X = AP site (Spacer C3), N = A, T, C and G) than the other three nucleobases with a dissociation constant Kd of ca. 1.0 μM; substituted methyl groups enhance the binding affinity to A and the selectivity for A over T, compared to the parent molecule, lumazine.
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U2 - 10.1039/b816876h
DO - 10.1039/b816876h
M3 - Article
C2 - 19057788
AN - SCOPUS:57249086260
SN - 1359-7345
SP - 6588
EP - 6590
JO - Chemical Communications
JF - Chemical Communications
IS - 48
ER -