9-azanoradamantane N-Oxyl (Nor-AZADO): A highly active organocatalyst for alcohol oxidation

Masaki Hayashi; Yusuke Sasano; Shota Nagasawa; Masatoshi Shibuya; Yoshiharu Iwabuchi

doi:10.1248/cpb.59.1570

9-azanoradamantane N-Oxyl (Nor-AZADO): A highly active organocatalyst for alcohol oxidation

Masaki Hayashi, Yusuke Sasano, Shota Nagasawa, Masatoshi Shibuya, Yoshiharu Iwabuchi

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

60 Citations (Scopus)

Abstract

A highly active organocatalyst for alcohol oxidation has been developed. 9-Azanoradamantane N-oxyl (Nor-AZADO 4), constituting an unhindered, stable nitroxyl radical, exhibits superior catalytic activity to 2,2,6,6- tetramethylpiperidine-1-oxyl (TEMPO) and AZADOs in the oxidation of alcohols to their corresponding carbonyl compounds.

Original language	English
Pages (from-to)	1570-1573
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	59
Issue number	12
DOIs	https://doi.org/10.1248/cpb.59.1570
Publication status	Published - 2011

Keywords

2-azaadamantane N-oxyl AZADO
Aerobic oxidation
Alcohol oxidation
Nitroxyl radical
Organocatalyst

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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title = "9-azanoradamantane N-Oxyl (Nor-AZADO): A highly active organocatalyst for alcohol oxidation",

abstract = "A highly active organocatalyst for alcohol oxidation has been developed. 9-Azanoradamantane N-oxyl (Nor-AZADO 4), constituting an unhindered, stable nitroxyl radical, exhibits superior catalytic activity to 2,2,6,6- tetramethylpiperidine-1-oxyl (TEMPO) and AZADOs in the oxidation of alcohols to their corresponding carbonyl compounds.",

keywords = "2-azaadamantane N-oxyl AZADO, Aerobic oxidation, Alcohol oxidation, Nitroxyl radical, Organocatalyst",

author = "Masaki Hayashi and Yusuke Sasano and Shota Nagasawa and Masatoshi Shibuya and Yoshiharu Iwabuchi",

year = "2011",

doi = "10.1248/cpb.59.1570",

language = "English",

volume = "59",

pages = "1570--1573",

journal = "Chemical and Pharmaceutical Bulletin",

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TY - JOUR

T1 - 9-azanoradamantane N-Oxyl (Nor-AZADO)

T2 - A highly active organocatalyst for alcohol oxidation

AU - Hayashi, Masaki

AU - Sasano, Yusuke

AU - Nagasawa, Shota

AU - Shibuya, Masatoshi

AU - Iwabuchi, Yoshiharu

PY - 2011

Y1 - 2011

N2 - A highly active organocatalyst for alcohol oxidation has been developed. 9-Azanoradamantane N-oxyl (Nor-AZADO 4), constituting an unhindered, stable nitroxyl radical, exhibits superior catalytic activity to 2,2,6,6- tetramethylpiperidine-1-oxyl (TEMPO) and AZADOs in the oxidation of alcohols to their corresponding carbonyl compounds.

AB - A highly active organocatalyst for alcohol oxidation has been developed. 9-Azanoradamantane N-oxyl (Nor-AZADO 4), constituting an unhindered, stable nitroxyl radical, exhibits superior catalytic activity to 2,2,6,6- tetramethylpiperidine-1-oxyl (TEMPO) and AZADOs in the oxidation of alcohols to their corresponding carbonyl compounds.

KW - 2-azaadamantane N-oxyl AZADO

KW - Aerobic oxidation

KW - Alcohol oxidation

KW - Nitroxyl radical

KW - Organocatalyst

UR - http://www.scopus.com/inward/record.url?scp=82955193070&partnerID=8YFLogxK

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EP - 1573

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 12

ER -

9-azanoradamantane N-Oxyl (Nor-AZADO): A highly active organocatalyst for alcohol oxidation

Abstract

Keywords

ASJC Scopus subject areas

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