A case of culture-negative endocarditis due to Streptococcus tigurinus

Hajime Kanamori, Risako Kakuta, Hisakazu Yano, Tomoyuki Suzuki, Yoshiaki Gu, Chihiro Oe, Shinya Inomata, Tetsuji Aoyagi, Masumitsu Hatta, Shiro Endo, Koichi Tokuda, David J. Weber, Yasuhiro Nakamura, Yoshikatsu Saiki, Mitsuo Kaku

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Culture-negative endocarditis remains a diagnostic and therapeutic challenge despite recent medical advances. Streptococcus tigurinus, a novel member of the Streptococcus mitis group, was first identified in Zurich. S.tigurinus possesses virulence determinants and causes invasive infections. We report a case of culture-negative endocarditis with serious complications due to S. tigurinus, which was identified by 16S ribosomal RNA gene sequence analysis of excised valve tissue specimens. This technique is useful for identification of the causative microorganism in patients with culture-negative endocarditis and may facilitate early diagnosis and appropriate antimicrobial treatment.

Original languageEnglish
Pages (from-to)138-140
Number of pages3
JournalJournal of Infection and Chemotherapy
Issue number2
Publication statusPublished - 2015 Feb 1


  • 16S ribosomal RNA gene analysis
  • Culture-negative endocarditis
  • Endocarditis
  • Streptococcus
  • Streptococcus tigurinus

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases


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