TY - JOUR
T1 - A Case of Diabetic Amyotrophy Associated With 3243 Mitochondrial Trna(Leu; Uur) Mutation And Successful Therapy With Coenzyme Q10
AU - Suzuki, Yoshihiko
AU - Atsumi, Yoshihito
AU - Hosokawa, Kazuhiro
AU - Uyama, Keiko
AU - Mokubo, Atsuko
AU - Asahina, Takayuki
AU - Murata, Chisato
AU - Matsuoka, Kempei
AU - Kadowaki, Hiroko
AU - Katagiri, Hideki
AU - Kadowaki, Takashi
AU - Oka, Yoshitomo
PY - 1995
Y1 - 1995
N2 - We report the case of 71-year-old male who was once diagnosed as having diabetic amyotrophy, because of pronounced wastingin proximal muscles, massive weight loss, and development of paresthesiain his legs. Afterwards, ragged red fibers and mitochondrial tRNA mutation at position 3243 were documentedin muscle biopsy. He had diabetes mellitus associated with 3243 mitochondrial DNA mutation, suggesting that clinically, diabetic amyotrophy may be overlapped with mitochondria-related disease entitiesin some parts. Coenzyme Q10 administration was effectivein relieving the symptomsin his legs, fatigue, and residual urinein his bladder. These were confirmed with the improvementin neurological parameters.in conclusion, this case gives important helpin understanding myopathyin diabetes. It would be important to check on the 3243 mitochondrial tRNA mutationin patients with diabetic amyotrophy and/or diabetic neuropathic symptoms.
AB - We report the case of 71-year-old male who was once diagnosed as having diabetic amyotrophy, because of pronounced wastingin proximal muscles, massive weight loss, and development of paresthesiain his legs. Afterwards, ragged red fibers and mitochondrial tRNA mutation at position 3243 were documentedin muscle biopsy. He had diabetes mellitus associated with 3243 mitochondrial DNA mutation, suggesting that clinically, diabetic amyotrophy may be overlapped with mitochondria-related disease entitiesin some parts. Coenzyme Q10 administration was effectivein relieving the symptomsin his legs, fatigue, and residual urinein his bladder. These were confirmed with the improvementin neurological parameters.in conclusion, this case gives important helpin understanding myopathyin diabetes. It would be important to check on the 3243 mitochondrial tRNA mutationin patients with diabetic amyotrophy and/or diabetic neuropathic symptoms.
KW - 3243 mitochondrial tRNA mutation
KW - Coenzyme Q10
KW - Diabetic amyotrophy
KW - Diabetic peripheral neuropathy
KW - Mitochondrial myopathy
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U2 - 10.1507/endocrj.42.141
DO - 10.1507/endocrj.42.141
M3 - Article
C2 - 7542975
AN - SCOPUS:0029056559
SN - 0918-8959
VL - 42
SP - 141
EP - 145
JO - Endocrine Journal
JF - Endocrine Journal
IS - 2
ER -
