A case of pancreatic cancer with local recurrence and liver metastases eight years after surgery

Hajime Taniguchi, Masamichi Mizuma, Fuyuhiko Motoi, Tomoya Abe, Ryo Okada, Kei Kawaguchi, Hideaki Karasawa, Kunihiro Masuda, Shinichi Yabuuchi, Koji Fukase, Naoaki Sakata, Takaho Okada, Kei Nakagawa, Hiroki Hayashi, Takanori Morikawa, Hiroshi Yoshida, Takeshi Naito, Yu Katayose, Shinichi Egawa, Michiaki Unno

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Here we report a rare case of late recurrence of pancreatic cancer 8 years after surgery. A woman in her mid-fifties was hopitalized for examination of epigastralgia. Computed tomography (CT) revealed a 4 cm nodule at the pancreatic head with suspected invasion of the superior mesenteric vein. She underwent pancreaticoduodenectomy with wedge resection of superior mesenteric vein and intraoperative radiation therapy. Pathological findings showed moderately differentiated tubular adenocarcinoma and T3N1 MO, Stage II B according to The Union for International Cancer Control (UICC) TNM classification. As adjuvant chemotherapy, 56 courses of gemcitabine (GEM) were administered in 3.5 years. Because of long-term use of GEM, common terminology criteria for adverse events (CTCAE) Grade 3 anemia occurred, and chemotherapy was discontinued. Tumor markers were evaluated every month and CT scans were taken every 6 months for 5 years. Subsequently, CT was performed annually. The patient was hospitalized for high-grade fever, 8.5 years after surgery. CT, magnetic resonance imaging (MRI) and positron emission tomography-computed tomography (PET-CT) detected local recurrence with liver metastases. GEM was administered again, but was ineffective. The patient died 9 years after surgery. In conclusion, even if long-term survival is achieved in pancreatic cancer, follow-ups should not be stopped.

Original languageEnglish
Pages (from-to)2193-2195
Number of pages3
JournalJapanese Journal of Cancer and Chemotherapy
Issue number12
Publication statusPublished - 2014 Nov


  • Late recurrence
  • Pancreatic cancer

ASJC Scopus subject areas

  • Medicine(all)


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