A case of primary mucosa-associated lymphoid tissue lymphoma of the vagina

Kousuke Yoshinaga, Jun Ichi Akahira, Hitoshi Niikura, Kiyoshi Ito, Takuya Moriya, Takashi Murakami, Jun Ichi Kameoka, Ryo Ichinohasama, Kunihiro Okamura, Nobuo Yaegashi

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


We report the first case of primary mucosa-associated lymphoid tissue (MALT) lymphoma of the vagina, the diagnosis of which is supported by genetic and immunophenotypic studies. A 65-year-old, para 2 woman presented to our hospital in July 1997 with a history of prolonged vaginal discharge. Although cytologic examination suggested possible malignancy, a biopsy of the vaginal wall was diagnosed as chronic inflammation. In June 2000, she underwent gynecologic examination because of anuria. Excisional biopsy revealed subepithelial infiltration of atypical lymphoid cells that stained for CD20, CD79a, and BCL-2; stained weakly for IgM; and did not stain for CD3, CD5, CD7, CD10, CD56, CD23, and IgD, suggesting marginal zone B-cell lineage. Monoclonality was detected by Southern blot analysis, and this patient was finally diagnosed as having primary MALT lymphoma of the vagina. She received 3 cycles of chemotherapy (THP-COP) and concurrent radiation to the whole pelvis. The patient is alive and well 40 months after treatment. Because the vagina is one of the mucosa-associated tissues, MALT lymphoma, though rare, must be included in the differential diagnosis of the vaginal neoplasms.

Original languageEnglish
Pages (from-to)1164-1166
Number of pages3
JournalHuman Pathology
Issue number9
Publication statusPublished - 2004 Sept


  • MALT
  • MALT lymphoma
  • Southern blot
  • immunohistochemistry
  • mucosa-associated lymphoid tissue
  • pirarubicin, cyclophosphamide, vincristine, and prednisolone
  • vagina

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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