TY - JOUR
T1 - A case of primary mucosa-associated lymphoid tissue lymphoma of the vagina
AU - Yoshinaga, Kousuke
AU - Akahira, Jun Ichi
AU - Niikura, Hitoshi
AU - Ito, Kiyoshi
AU - Moriya, Takuya
AU - Murakami, Takashi
AU - Kameoka, Jun Ichi
AU - Ichinohasama, Ryo
AU - Okamura, Kunihiro
AU - Yaegashi, Nobuo
N1 - Funding Information:
Supported in part by a grant-in-aid for scientific research from the Ministry of Health and Welfare, Tokyo, Japan; a grant-in-aid from the Ministry of Education, Science and Culture, Tokyo, Japan; a grant-in-aid from Kurokawa Cancer Research Foundation, Sendai, Japan; and a grant-in-aid from the Japan Society of Gynecologic Oncology (JSGO), Tokyo, Japan.
PY - 2004/9
Y1 - 2004/9
N2 - We report the first case of primary mucosa-associated lymphoid tissue (MALT) lymphoma of the vagina, the diagnosis of which is supported by genetic and immunophenotypic studies. A 65-year-old, para 2 woman presented to our hospital in July 1997 with a history of prolonged vaginal discharge. Although cytologic examination suggested possible malignancy, a biopsy of the vaginal wall was diagnosed as chronic inflammation. In June 2000, she underwent gynecologic examination because of anuria. Excisional biopsy revealed subepithelial infiltration of atypical lymphoid cells that stained for CD20, CD79a, and BCL-2; stained weakly for IgM; and did not stain for CD3, CD5, CD7, CD10, CD56, CD23, and IgD, suggesting marginal zone B-cell lineage. Monoclonality was detected by Southern blot analysis, and this patient was finally diagnosed as having primary MALT lymphoma of the vagina. She received 3 cycles of chemotherapy (THP-COP) and concurrent radiation to the whole pelvis. The patient is alive and well 40 months after treatment. Because the vagina is one of the mucosa-associated tissues, MALT lymphoma, though rare, must be included in the differential diagnosis of the vaginal neoplasms.
AB - We report the first case of primary mucosa-associated lymphoid tissue (MALT) lymphoma of the vagina, the diagnosis of which is supported by genetic and immunophenotypic studies. A 65-year-old, para 2 woman presented to our hospital in July 1997 with a history of prolonged vaginal discharge. Although cytologic examination suggested possible malignancy, a biopsy of the vaginal wall was diagnosed as chronic inflammation. In June 2000, she underwent gynecologic examination because of anuria. Excisional biopsy revealed subepithelial infiltration of atypical lymphoid cells that stained for CD20, CD79a, and BCL-2; stained weakly for IgM; and did not stain for CD3, CD5, CD7, CD10, CD56, CD23, and IgD, suggesting marginal zone B-cell lineage. Monoclonality was detected by Southern blot analysis, and this patient was finally diagnosed as having primary MALT lymphoma of the vagina. She received 3 cycles of chemotherapy (THP-COP) and concurrent radiation to the whole pelvis. The patient is alive and well 40 months after treatment. Because the vagina is one of the mucosa-associated tissues, MALT lymphoma, though rare, must be included in the differential diagnosis of the vaginal neoplasms.
KW - MALT
KW - MALT lymphoma
KW - Southern blot
KW - THP-COP
KW - immunohistochemistry
KW - mucosa-associated lymphoid tissue
KW - pirarubicin, cyclophosphamide, vincristine, and prednisolone
KW - vagina
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U2 - 10.1016/j.humpath.2004.06.002
DO - 10.1016/j.humpath.2004.06.002
M3 - Article
C2 - 15343521
AN - SCOPUS:4444360457
SN - 0046-8177
VL - 35
SP - 1164
EP - 1166
JO - Human Pathology
JF - Human Pathology
IS - 9
ER -