TY - JOUR
T1 - A case of prostatic adenocarcinoma with Paneth cell-like appearance
AU - Nakamura, Yasuhiro
AU - Fujishima, Fumiyoshi
AU - Watanabe, Mika
AU - Taniuchi, Shinji
AU - Ishida, Kazuyuki
AU - Ishidoya, Shigeto
AU - Arai, Yoichi
AU - Sasano, Hironobu
PY - 2011/6/8
Y1 - 2011/6/8
N2 - Paneth cell-like appearance of prostatic carcinoma cells with eosinophilic cytoplasmic granules is rarely reported, and is known to be associated with neuroendocrine differentiation of carcinoma cells. We report a case of prostatic adenocarcinoma with Paneth cell-like appearance that was localized next to conventional adenocarcinoma, and demonstrate its neuroendocrine differentiation by using immuno-histochemical analysis. Paneth cell-like appearance of prostatic carcinoma cells should be recognized and considered as a sign of neuroendocrine differentiation due to the possible association with resistance to hormone therapy.
AB - Paneth cell-like appearance of prostatic carcinoma cells with eosinophilic cytoplasmic granules is rarely reported, and is known to be associated with neuroendocrine differentiation of carcinoma cells. We report a case of prostatic adenocarcinoma with Paneth cell-like appearance that was localized next to conventional adenocarcinoma, and demonstrate its neuroendocrine differentiation by using immuno-histochemical analysis. Paneth cell-like appearance of prostatic carcinoma cells should be recognized and considered as a sign of neuroendocrine differentiation due to the possible association with resistance to hormone therapy.
KW - Neuroendocrine differentiation
KW - Paneth cell-like feature
KW - Prostatic adenocarcinoma
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M3 - Article
C2 - 21574107
AN - SCOPUS:79957938762
SN - 1233-9687
VL - 62
SP - 60
EP - 64
JO - Polish Journal of Pathology
JF - Polish Journal of Pathology
IS - 1
ER -