A case report of cerebellar pleomorphic xanthoastrocytoma

Yui Mano, Masayuki Kanamori, Yukihiko Sonoda, Toshihiro Kumabe, Mika Watanabe, Teiji Tominaga

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Pleomorphic xanthoastrocytoma (PXA) is a type of astrocytic neoplasm, classified as WHO grade II, which mainly occurs supratentorially, and rarely infratentorially. We report an unusual case of PXA in the cerebellar vermis. A 36-year-old man presented with headache and gait disturbance. Magnetic resonance imaging and computed tomography demonstrated a mass lesion with cyst in the cerebellar vermis. The patient underwent total resection. Histological examination demonstrated nuclear and cytoplasmic pleomorphism, and xanthomatous change. Immunohistochemical examination demonstrated xanthomatous cells expressing glial fibrillary acidic protein. The histological diagnosis was PXA of the cerebellar vermis. The patient did not receive radiation therapy or chemotherapy after resection, and has experienced no recurrence for 12 months. This case suggests that PXA should be considered in the differential diagnosis of cystic lesion in the cerebellar vermis.

Original languageEnglish
Pages (from-to)586-590
Number of pages5
JournalNeurological Surgery
Issue number6
Publication statusPublished - 2009 Jun


  • Apparent diffusion coefficient
  • Cerebellum
  • Histology
  • Magnetic resonance imaging
  • Pleomorphic xanthoastrocytoma


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