A Combinatorial Synthesis of a Macrosphelide Library Utilizing a Palladium-Catalyzed Carbonylation on a Polymer Support

Takashi Takahashi; Shin Ichi Kusaka; Takayuki Doi; Toshiaki Sunazuka; Satoshi Omura

doi:10.1002/anie.200352229

A Combinatorial Synthesis of a Macrosphelide Library Utilizing a Palladium-Catalyzed Carbonylation on a Polymer Support

Takashi Takahashi, Shin Ichi Kusaka, Takayuki Doi, Toshiaki Sunazuka, Satoshi Omura

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

93 Citations (Scopus)

Abstract

Supported total synthesis: The combinatorial synthesis of a 122-membered macrosphelide library including macrosphelides A, C, E, and F (see picture) has been achieved based on a unique strategy for a three-component coupling utilizing a palladium-catalyzed chemoselective carbonylation and an unprecedented macrolactonization on a polymer support.

Original language	English
Pages (from-to)	5230-5234
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	42
Issue number	42
DOIs	https://doi.org/10.1002/anie.200352229
Publication status	Published - 2003 Nov 3

Keywords

Chemoselectivity
Combinatorial chemistry
Macrosphelides
Palladium
Solid-phase synthesis

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10.1002/anie.200352229

Cite this

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AU - Kusaka, Shin Ichi

AU - Doi, Takayuki

AU - Sunazuka, Toshiaki

AU - Omura, Satoshi

PY - 2003/11/3

Y1 - 2003/11/3

N2 - Supported total synthesis: The combinatorial synthesis of a 122-membered macrosphelide library including macrosphelides A, C, E, and F (see picture) has been achieved based on a unique strategy for a three-component coupling utilizing a palladium-catalyzed chemoselective carbonylation and an unprecedented macrolactonization on a polymer support.

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KW - Chemoselectivity

KW - Combinatorial chemistry

KW - Macrosphelides

KW - Palladium

KW - Solid-phase synthesis

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A Combinatorial Synthesis of a Macrosphelide Library Utilizing a Palladium-Catalyzed Carbonylation on a Polymer Support

Abstract

Keywords

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