A comparative analysis of clinicopathological factors between esophageal small cell and basaloid squamous cell carcinoma

Hirotaka Ishida, Atsuko Kasajima, Yu Onodera, Takuro Konno, Shota Maruyama, Hiroshi Okamoto, Chiaki Sato, Takahiro Heishi, Tadashi Sakurai, Yusuke Taniyama, Masanobu Takahashi, Fumiyoshi Fujishima, Keiichi Jingu, Chikashi Ishioka, Hironobu Sasano, Takashi Kamei

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9 Citations (Scopus)


Esophageal small cell carcinoma (E-SmCC) and basaloid squamous cell carcinomas (BSCCs) are both highly aggressive malignancies, but their detailed differences in clinical behaviors have remained virtually unknown. In addition, treatment strategies of the patients with E-SmCC have not been established. 29 cases of E-SmCC and 39 with BSCC were examined in this study to clarify the clinical features and outcome of the patients with E-SmCC and to compare the findings with those of BSCC. E-SmCCs presented a more advanced status than BSCC (TNM Stage: P=.002). Esophagectomy was performed in 15 small cell carcinoma patients and 14 were treated with non-surgical/systemic therapy. The clinical outcome of the small cell carcinoma cases was significantly worse than those with BSCC (P=.001), but results of a stage-stratified analysis revealed that the Stage I small cell carcinoma patients presented favorable prognosis (3-year survival rate 100%, n=4). In contrast, among those with Stage II-IV, clinical outcome tended to be better in the systemic therapy group (3-year survival rate 49%, n=13) than the surgically treated group (3-year survival rate 0%, n=12). E-SmCC was a more aggressive neoplasm than BSCC. However, early detection could possibly improve the clinical outcome of patients with E-SmCC. Systemic therapy could also benefit the patients with advanced disease (Stage II-IV).

Original languageEnglish
Article numbere14363
JournalMedicine (United States)
Issue number8
Publication statusPublished - 2019 Feb 1


  • Basaloid squamous cell carcinoma
  • esophageal small cell carcinoma
  • prognosis
  • treatment


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