A concentration-based microscale method for 18F-nucleophilic substitutions and its testing on the one-pot radiosynthesis of [18F]FET and [18F]fallypride

Ren Iwata; Kazunori Terasaki; Yoichi Ishikawa; Ryuichi Harada; Shozo Furumoto; Kazuhiko Yanai; Claudio Pascali

doi:10.1016/j.apradiso.2020.109361

A concentration-based microscale method for ¹⁸F-nucleophilic substitutions and its testing on the one-pot radiosynthesis of [¹⁸F]FET and [¹⁸F]fallypride

Ren Iwata, Kazunori Terasaki, Yoichi Ishikawa, Ryuichi Harada, Shozo Furumoto, Kazuhiko Yanai, Claudio Pascali

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

When applied to a radiosynthesis, a microscale approach can help to save precursor and improve yields. Thus, a 5–10 μL microscale method based on a concentration procedure was developed and applied to the radiosynthesis of [¹⁸F]FET and [¹⁸F]fallypride. In spite of using an amount of precursor ca. 100 times smaller, radiochemical yields were comparable or even higher than those reported in literature. Because of the very low reaction volumes, the possible effects of concentrated dose of activity and carrier fluoride were also investigated.

Original language	English
Article number	109361
Journal	Applied Radiation and Isotopes
Volume	166
DOIs	https://doi.org/10.1016/j.apradiso.2020.109361
Publication status	Published - 2020 Dec

Keywords

Concentration by evaporation
Microscale reaction
[F]fallypride
[F]FET

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10.1016/j.apradiso.2020.109361

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title = "A concentration-based microscale method for 18F-nucleophilic substitutions and its testing on the one-pot radiosynthesis of [18F]FET and [18F]fallypride",

abstract = "When applied to a radiosynthesis, a microscale approach can help to save precursor and improve yields. Thus, a 5–10 μL microscale method based on a concentration procedure was developed and applied to the radiosynthesis of [18F]FET and [18F]fallypride. In spite of using an amount of precursor ca. 100 times smaller, radiochemical yields were comparable or even higher than those reported in literature. Because of the very low reaction volumes, the possible effects of concentrated dose of activity and carrier fluoride were also investigated.",

keywords = "Concentration by evaporation, Microscale reaction, [F]fallypride, [F]FET",

author = "Ren Iwata and Kazunori Terasaki and Yoichi Ishikawa and Ryuichi Harada and Shozo Furumoto and Kazuhiko Yanai and Claudio Pascali",

note = "Funding Information: This work was supported by JSPS KAKENHI Grant Number 16H05383 . Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

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T1 - A concentration-based microscale method for 18F-nucleophilic substitutions and its testing on the one-pot radiosynthesis of [18F]FET and [18F]fallypride

AU - Iwata, Ren

AU - Terasaki, Kazunori

AU - Ishikawa, Yoichi

AU - Harada, Ryuichi

AU - Furumoto, Shozo

AU - Yanai, Kazuhiko

AU - Pascali, Claudio

PY - 2020/12

Y1 - 2020/12

N2 - When applied to a radiosynthesis, a microscale approach can help to save precursor and improve yields. Thus, a 5–10 μL microscale method based on a concentration procedure was developed and applied to the radiosynthesis of [18F]FET and [18F]fallypride. In spite of using an amount of precursor ca. 100 times smaller, radiochemical yields were comparable or even higher than those reported in literature. Because of the very low reaction volumes, the possible effects of concentrated dose of activity and carrier fluoride were also investigated.

AB - When applied to a radiosynthesis, a microscale approach can help to save precursor and improve yields. Thus, a 5–10 μL microscale method based on a concentration procedure was developed and applied to the radiosynthesis of [18F]FET and [18F]fallypride. In spite of using an amount of precursor ca. 100 times smaller, radiochemical yields were comparable or even higher than those reported in literature. Because of the very low reaction volumes, the possible effects of concentrated dose of activity and carrier fluoride were also investigated.

KW - Concentration by evaporation

KW - Microscale reaction

KW - [F]fallypride

KW - [F]FET

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JO - Applied Radiation and Isotopes

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ER -

A concentration-based microscale method for ¹⁸F-nucleophilic substitutions and its testing on the one-pot radiosynthesis of [¹⁸F]FET and [¹⁸F]fallypride

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Keywords

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