A concise route to (+)-lactacystin

Hidenori Ooi, Norihisa Ishibashi, Yoshiharu Iwabuchi, Jun Ishihara, Susumi Hatakeyama

Research output: Contribution to journalArticlepeer-review

83 Citations (Scopus)


A facile chromatography-free route to Kang's intermediate for the synthesis of (+)-lactacystin, a potent proteasome inhibitor, has been developed starting with Brown's asymmetric crotylation of tert-butyl 5-formyl-2,2-dimethyl-1,3- dioxan-5-ylcarbamate, easily available from 2-amino-2-(hydroxymethyl)propane-1, 3-diol (Tris).

Original languageEnglish
Pages (from-to)7765-7768
Number of pages4
JournalJournal of Organic Chemistry
Issue number22
Publication statusPublished - 2004 Oct 29


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