A concise route to (+)-lactacystin

Hidenori Ooi; Norihisa Ishibashi; Yoshiharu Iwabuchi; Jun Ishihara; Susumi Hatakeyama

doi:10.1021/jo048817o

A concise route to (+)-lactacystin

Hidenori Ooi, Norihisa Ishibashi, Yoshiharu Iwabuchi, Jun Ishihara, Susumi Hatakeyama

PHA - Molecular Pharmaceutical Science

Nagasaki University

Research output: Contribution to journal › Article › peer-review

83 Citations (Scopus)

Abstract

A facile chromatography-free route to Kang's intermediate for the synthesis of (+)-lactacystin, a potent proteasome inhibitor, has been developed starting with Brown's asymmetric crotylation of tert-butyl 5-formyl-2,2-dimethyl-1,3- dioxan-5-ylcarbamate, easily available from 2-amino-2-(hydroxymethyl)propane-1, 3-diol (Tris).

Original language	English
Pages (from-to)	7765-7768
Number of pages	4
Journal	Journal of Organic Chemistry
Volume	69
Issue number	22
DOIs	https://doi.org/10.1021/jo048817o
Publication status	Published - 2004 Oct 29

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author = "Hidenori Ooi and Norihisa Ishibashi and Yoshiharu Iwabuchi and Jun Ishihara and Susumi Hatakeyama",

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AU - Ooi, Hidenori

AU - Ishibashi, Norihisa

AU - Iwabuchi, Yoshiharu

AU - Ishihara, Jun

AU - Hatakeyama, Susumi

PY - 2004/10/29

Y1 - 2004/10/29

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A concise route to (+)-lactacystin

Abstract

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