@article{a7432cb1e44a4bca95857bb013ad96b1,
title = "A concise total synthesis of (-)-indolactam v",
abstract = "One-pot synthesis of tryptophanol derivative from N-Boc-aziridine and indole has been developed. The ring opening reaction of the aziridine takes place smoothly at -30°C in a regioselective manner and tolerates a wide range of functional groups including halogens attached to the aromatic ring, which was also performed on a gram scale. The resulting tryptophanol derivative was converted to (-)-indolactam V from commercially available 4-bromoindole through a copper-mediated aryl amination in nine steps with an overall yield of 32%.",
keywords = "Amino acid, Aziridine, Indolactam, Indole, Total synthesis",
author = "Toshiharu Noji and Kentaro Okano and Hidetoshi Tokuyama",
note = "Funding Information: This work was financially supported by the Cabinet Office, Government of Japan through its {\textquoteleft} Funding Program for Next Generation World-Leading Researchers ( LS008 ), the JSPS KAKENHI , a Grant-in-Aid for Scientific Research (A) ( 26253001 ), Platform for Drug Discovery, Informatics, and Structural Life Science for H.T., a Grant-in-Aid for Scientific Research (C) ( 25460003 ) and a Grant-in-Aid for Scientific Research on Innovative Areas {\textquoteleft}Molecular Activation Directed toward Straightforward Synthesis{\textquoteright} ( 25105705 ) for K.O., and JSPS predoctoral fellowship and Tohoku University Campus Asia Project for T.N. Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd. All rights reserved.",
year = "2015",
month = may,
day = "26",
doi = "10.1016/j.tet.2015.04.015",
language = "English",
volume = "71",
pages = "3833--3837",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Ltd.",
number = "23",
}