TY - GEN
T1 - A controlled-release capsule device for transscleral drug delivery to the retina
AU - Kaji, Hirokazu
AU - Nagai, Nobuhiro
AU - Yamada, Takuya
AU - Nishizawa, Matsuhiko
AU - Abe, Toshiaki
PY - 2012
Y1 - 2012
N2 - We report the design and testing of a transscleral drug delivery system that is implantable in the episclera and allows for controlled release of brain-derived neurotrophic factor (BDNF) or other protein-type drugs with zero-order kinetics. The microfabricated capsule consists of a drug reservoir sealed with a controlled-release membrane that contains interconnected collagen microparticles (COLs), which are the routes for drug permeation. The drug kinetics can be controlled by changing the drug formulation and/or the membrane COL density so that the size of the bursts is reduced, which extends the release period. When capsules were sutured onto sclerae of rabbit eyes, a drug mimic was found to spread to the retinal pigment epithelium. Implantation of the device was easy, and it did not damage the eye tissues.
AB - We report the design and testing of a transscleral drug delivery system that is implantable in the episclera and allows for controlled release of brain-derived neurotrophic factor (BDNF) or other protein-type drugs with zero-order kinetics. The microfabricated capsule consists of a drug reservoir sealed with a controlled-release membrane that contains interconnected collagen microparticles (COLs), which are the routes for drug permeation. The drug kinetics can be controlled by changing the drug formulation and/or the membrane COL density so that the size of the bursts is reduced, which extends the release period. When capsules were sutured onto sclerae of rabbit eyes, a drug mimic was found to spread to the retinal pigment epithelium. Implantation of the device was easy, and it did not damage the eye tissues.
KW - Controlled release
KW - Drug delivery system
KW - Retinal neuroprotection
KW - Transscleral delivery
UR - http://www.scopus.com/inward/record.url?scp=84901804529&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84901804529&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84901804529
SN - 9780979806452
T3 - Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
SP - 452
EP - 454
BT - Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
PB - Chemical and Biological Microsystems Society
T2 - 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
Y2 - 28 October 2012 through 1 November 2012
ER -