A delicate balance: CD73-generated adenosine limits the severity of graft vs. Host disease but also constrains the allogeneic graft vs. Tumor effect

Linda F. Thompson; Hiroki Tsukamoto; Petya Chernogorova; Robert Zeiser

doi:10.4161/onci.22107

A delicate balance: CD73-generated adenosine limits the severity of graft vs. Host disease but also constrains the allogeneic graft vs. Tumor effect

Linda F. Thompson, Hiroki Tsukamoto, Petya Chernogorova, Robert Zeiser

PHA - Pharmacy

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The utility of allogeneic stem cell transplantation for treating hematologic malignancies is enhanced by the graft vs. tumor (GvT) effect, but limited by graft vs. host disease (GvHD). Studies involving the inhibition of CD73 by genetic or pharmacologic means suggest that the levels of CD73-generated adenosine may be manipulated to control GvHD, while maintaining the GvT effect.

Original language	English
Article number	e22107
Journal	OncoImmunology
Volume	2
Issue number	1
DOIs	https://doi.org/10.4161/onci.22107
Publication status	Published - 2013 Jan

Keywords

Adenosine receptor
CD73
Graft vs
Host disease
Tumor effect

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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10.4161/onci.22107

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KW - Tumor effect

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A delicate balance: CD73-generated adenosine limits the severity of graft vs. Host disease but also constrains the allogeneic graft vs. Tumor effect

Abstract

Keywords

ASJC Scopus subject areas

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