TY - JOUR
T1 - A dimeric pyrrocidine from Neonectria ramulariae is an inhibitor of prolyl oligopeptidase
AU - Shiono, Yoshihito
AU - Kosukegawa, Azusa
AU - Koseki, Takuya
AU - Murayama, Tetsuya
AU - Kwon, Eunsang
AU - Uesugi, Shota
AU - Kimura, Ken Ichi
PY - 2012/3
Y1 - 2012/3
N2 - Four novel alkaloids, bispyrrocidine (5), the epoxy derivative of pyrrocidine B (6), 19-O-methyl-pyrrrocidine B (7) and 19-O-ethyl-pyrrrocidine B (8) were isolated from the endophytic fungus Neonectria ramulariae Wollenw KS-246. Their structures were elucidated using 1D- and 2D-NMR spectroscopy. Compound 6 exhibited cytotoxicity against HL60 cells (IC 50 4.6 μM), whereas 5 showed specific inhibitory activity against prolyl oligopeptidase (IC 50 2.6 μM) in a non-competitive manner.
AB - Four novel alkaloids, bispyrrocidine (5), the epoxy derivative of pyrrocidine B (6), 19-O-methyl-pyrrrocidine B (7) and 19-O-ethyl-pyrrrocidine B (8) were isolated from the endophytic fungus Neonectria ramulariae Wollenw KS-246. Their structures were elucidated using 1D- and 2D-NMR spectroscopy. Compound 6 exhibited cytotoxicity against HL60 cells (IC 50 4.6 μM), whereas 5 showed specific inhibitory activity against prolyl oligopeptidase (IC 50 2.6 μM) in a non-competitive manner.
KW - Bispyrrocidine
KW - Endophyte
KW - Neonectria ramulariae
KW - Prolyl oligopeptidase inhibitor
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U2 - 10.1016/j.phytol.2011.10.008
DO - 10.1016/j.phytol.2011.10.008
M3 - Article
AN - SCOPUS:84856750355
SN - 1874-3900
VL - 5
SP - 91
EP - 95
JO - Phytochemistry Letters
JF - Phytochemistry Letters
IS - 1
ER -