@article{93ae98625b7848fc9fb5dca5f6c8b7c7,
title = "A facile synthesis of (+)/(−)-pentenomycin I and analogs, and their antimicrobial evaluation",
abstract = "This study reported a stereoselective synthesis of (+)/(+)-pentenomycin I in 4–5 steps through regioselective silylation, optical resolution and dihydroxylation, followed by an olefin formation, from a known racemic cyclopentenone prepared from 2-deoxy-D-glucose. We also accomplished the transformation of a common intermediate into a variety of analogs. In addition, the antimicrobial activities of the pentenomycin analogs were evaluated, which revealed important structural factors of pentenomycins for the antimicrobial activities.",
keywords = "Antimicrobial susceptibility testing, Pentenomycin, Structure-activity relationships, Total synthesis",
author = "Takaaki Kamishima and Masato Suzuki and Shigenobu Aoyagi and Toshihiro Watanabe and Yoshitaka Koseki and Hitoshi Kasai",
note = "Funding Information: We would like to thank Emeritus Profs. Kunio Arai, Dr. Hideo Hattori and Dr. Toshiyuki Nonaka of FromSeeds Co., who provided fruitful discussion and supplied materials. We are very grateful to Prof. Fumi Nagatsugi, Prof. Hidetoshi Oikawa and Assistant Prof. Anh T. N. Dao of Tohoku University for their help on the compounds measurements. This work was performed under the Cooperative Research Program of “Network Joint Research Center for Materials and Devices. This work was supported by a Grant-in-Aid for Research Program on Emerging and Re-emerging Infectious Diseases ( JP18fk0108020 for M.S.) from Japan Agency for Medical Research and Development (AMED), Japan. Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",
year = "2019",
month = may,
day = "16",
doi = "10.1016/j.tetlet.2019.04.026",
language = "English",
volume = "60",
pages = "1375--1378",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "20",
}