TY - JOUR
T1 - A feline CD2 homologue interacts with human red blood cells
AU - Shimojima, Masayuki
AU - Nishimura, Yorihiro
AU - Miyazawa, Takayuki
AU - Kato, Kentaro
AU - Nakamura, Kazuya
AU - Izumiya, Yoshihiro
AU - Akashi, Hiroomi
AU - Tohya, Yukinobu
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2002
Y1 - 2002
N2 - A cDNA encoding a feline homologue of CD2 (fCD2) was identified. Several amino acids (aa) important for ligand interaction, molecular folding or signal transduction, found in other mammalian CD2, were found to be highly conserved in the predicted fCD2 aa sequence. fCD2-expressing cells were able to form rosettes with human red blood cells (probably via human CD58), and the rosette formation was inhibited by an anti-fCD2 monoclonal antibody. These results are indicative of the similarity of feline and human CD2 structures. fCD2 was found to be expressed in feline peripheral blood T lymphocytes, monocytes and cultured lymphoid cells.
AB - A cDNA encoding a feline homologue of CD2 (fCD2) was identified. Several amino acids (aa) important for ligand interaction, molecular folding or signal transduction, found in other mammalian CD2, were found to be highly conserved in the predicted fCD2 aa sequence. fCD2-expressing cells were able to form rosettes with human red blood cells (probably via human CD58), and the rosette formation was inhibited by an anti-fCD2 monoclonal antibody. These results are indicative of the similarity of feline and human CD2 structures. fCD2 was found to be expressed in feline peripheral blood T lymphocytes, monocytes and cultured lymphoid cells.
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U2 - 10.1046/j.0019-2805.2001.01371.x
DO - 10.1046/j.0019-2805.2001.01371.x
M3 - Article
C2 - 11918698
AN - SCOPUS:0036229651
SN - 0019-2805
VL - 105
SP - 360
EP - 366
JO - Immunology
JF - Immunology
IS - 3
ER -