A formal total synthesis of taxol aided by an automated synthesizer

Takayuki Doi, Shinichiro Fuse, Shigeru Miyamoto, Kazuoki Nakai, Daisuke Sasuga, Takashi Takahashi

Research output: Contribution to journalArticlepeer-review

109 Citations (Scopus)


A 36-step synthesis was carried out in automated synthesizers to provide a synthetic key intermediate of taxol. A key step involved a microwave-assisted alkylation reaction to construct the ABC ring system from an AC precursor. Subsequent formation of the D ring afforded baccatin III, a well-known precursor of taxol.

Original languageEnglish
Pages (from-to)370-383
Number of pages14
JournalChemistry - An Asian Journal
Issue number3
Publication statusPublished - 2006


  • Antitumor agents
  • Automated synthesis
  • Natural products
  • Synthetic methods
  • Total synthesis


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