A formal total synthesis of taxol aided by an automated synthesizer

Takayuki Doi; Shinichiro Fuse; Shigeru Miyamoto; Kazuoki Nakai; Daisuke Sasuga; Takashi Takahashi

doi:10.1002/asia.200600156

A formal total synthesis of taxol aided by an automated synthesizer

Takayuki Doi, Shinichiro Fuse, Shigeru Miyamoto, Kazuoki Nakai, Daisuke Sasuga, Takashi Takahashi

PHA - Molecular Pharmaceutical Science

Tokyo Institute of Technology

Research output: Contribution to journal › Article › peer-review

109 Citations (Scopus)

Abstract

A 36-step synthesis was carried out in automated synthesizers to provide a synthetic key intermediate of taxol. A key step involved a microwave-assisted alkylation reaction to construct the ABC ring system from an AC precursor. Subsequent formation of the D ring afforded baccatin III, a well-known precursor of taxol.

Original language	English
Pages (from-to)	370-383
Number of pages	14
Journal	Chemistry - An Asian Journal
Volume	1
Issue number	3
DOIs	https://doi.org/10.1002/asia.200600156
Publication status	Published - 2006

Keywords

Antitumor agents
Automated synthesis
Natural products
Synthetic methods
Total synthesis

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10.1002/asia.200600156

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AU - Takahashi, Takashi

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A formal total synthesis of taxol aided by an automated synthesizer

Abstract

Keywords

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