@inproceedings{ff26d39f885249d3ad99bfdde0c49528,
title = "A freestanding microfluidic-based thermocouple biosensor for enzyme-catalyzed reaction analysis",
abstract = "This research reports a multifunctional thermal biosensor that has thermocouple structures integrated with freestanding microfluidic channels for bio-sensing based on enzyme-catalyzed reactions. The free-standing SU-8 polymer-based microfluidic measurement chamber allows sensitive measurement of small volumes of liquid samples and reduces heat loss to improve the sensitivity. The fabricated thermocouple biosensor is capable of enzyme-catalyzed reaction detection for healthcare applications. Reactive enzymes are immobilized on microspheres packed in the chambers. The fabricated thermocouple biosensor shows a sensitivity of approximately 0.5 V/W and a thermal time constant of less than 100ms. The Seebeck-coefficient of thermocouple biosensor obtains a sensitivity of 1.1mV/°C with the measurement of IR thermometry. The results demonstrate that the sensor was capable of enzyme-catalyzed reaction detection for healthcare application.",
keywords = "Biosensor, Enzyme immobilization, Fluidic struture, Thermocouple",
author = "Zhuqing Wang and Mitsuteru Kimura and Naoki Inomata and Takahito Ono",
note = "Publisher Copyright: {\textcopyright} 2016 IEEE.; 11th IEEE Annual International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2016 ; Conference date: 17-04-2016 Through 20-04-2016",
year = "2016",
month = nov,
day = "28",
doi = "10.1109/NEMS.2016.7758200",
language = "English",
series = "2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2016",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "58--61",
booktitle = "2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2016",
address = "United States",
}