TY - JOUR
T1 - A genome-wide association study on confection consumption in a Japanese population
T2 - The Japan Multi-Institutional Collaborative Cohort Study
AU - Suzuki, Taro
AU - Nakamura, Yasuyuki
AU - Doi, Yukio
AU - Narita, Akira
AU - Shimizu, Atsushi
AU - Imaeda, Nahomi
AU - Goto, Chiho
AU - Matsui, Kenji
AU - Kadota, Aya
AU - Miura, Katsuyuki
AU - Nakatochi, Masahiro
AU - Tanaka, Keitaro
AU - Hara, Megumi
AU - Ikezaki, Hiroaki
AU - Murata, Masayuki
AU - Takezaki, Toshiro
AU - Nishimoto, Daisaku
AU - Matsuo, Keitaro
AU - Oze, Isao
AU - Kuriyama, Nagato
AU - Ozaki, Etsuko
AU - Mikami, Haruo
AU - Nakamura, Yohko
AU - Watanabe, Miki
AU - Suzuki, Sadao
AU - Katsuura-Kamano, Sakurako
AU - Arisawa, Kokichi
AU - Kuriki, Kiyonori
AU - Momozawa, Yukihide
AU - Kubo, Michiaki
AU - Takeuchi, Kenji
AU - Kita, Yoshikuni
AU - Wakai, Kenji
N1 - Funding Information:
This study was supported by Grants-in-Aid for Scientific Research for Priority Areas of Cancer (no. 17015018) and Innovative Areas (no. 221S0001), and by JSPS KAKENHI grants no. 19H03902, 16H06277 (CoBiA) and 15H02524) from the Japanese Ministry of Education, Culture, Sports, Science and Technology. This work was also supported in part by a Grant-in-Aid from the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant B Numbers 24390165, 20390184 and 17390186. This study was supported in part by funding for the BioBank Japan Project from the Japan Agency for Medical Research and development since April 2015, and the Ministry of Education, Culture, Sports, Science and Technology from April 2003 to March 2015.
Publisher Copyright:
©
PY - 2021/12/28
Y1 - 2021/12/28
N2 - Differences in individual eating habits may be influenced by genetic factors, in addition to cultural, social or environmental factors. Previous studies suggested that genetic variants within sweet taste receptor genes family were associated with sweet taste perception and the intake of sweet foods. The aim of this study was to conduct a genome-wide association study (GWAS) to find genetic variations that affect confection consumption in a Japanese population. We analysed GWAS data on confection consumption using 14 073 participants from the Japan Multi-Institutional Collaborative Cohort study. We used a semi-quantitative FFQ to estimate food intake that was validated previously. Association of the imputed variants with confection consumption was performed by linear regression analysis with adjustments for age, sex, total energy intake and principal component analysis components 1-3. Furthermore, the analysis was repeated adjusting for alcohol intake (g/d) in addition to the above-described variables. We found 418 SNP located in 12q24 that were associated with confection consumption. SNP with the ten lowest P-values were located on nine genes including at the BRAP, ACAD10 and aldehyde dehydrogenase 2 regions on 12q24.12-13. After adjustment for alcohol intake, no variant was associated with confections intake with genome-wide significance. In conclusion, we found a significant number of SNP located on 12q24 genes that were associated with confections intake before adjustment for alcohol intake. However, all of them lost statistical significance after adjustment for alcohol intake.
AB - Differences in individual eating habits may be influenced by genetic factors, in addition to cultural, social or environmental factors. Previous studies suggested that genetic variants within sweet taste receptor genes family were associated with sweet taste perception and the intake of sweet foods. The aim of this study was to conduct a genome-wide association study (GWAS) to find genetic variations that affect confection consumption in a Japanese population. We analysed GWAS data on confection consumption using 14 073 participants from the Japan Multi-Institutional Collaborative Cohort study. We used a semi-quantitative FFQ to estimate food intake that was validated previously. Association of the imputed variants with confection consumption was performed by linear regression analysis with adjustments for age, sex, total energy intake and principal component analysis components 1-3. Furthermore, the analysis was repeated adjusting for alcohol intake (g/d) in addition to the above-described variables. We found 418 SNP located in 12q24 that were associated with confection consumption. SNP with the ten lowest P-values were located on nine genes including at the BRAP, ACAD10 and aldehyde dehydrogenase 2 regions on 12q24.12-13. After adjustment for alcohol intake, no variant was associated with confections intake with genome-wide significance. In conclusion, we found a significant number of SNP located on 12q24 genes that were associated with confections intake before adjustment for alcohol intake. However, all of them lost statistical significance after adjustment for alcohol intake.
KW - Alcohol intake confounding
KW - Aldehyde dehydrogenase 2
KW - Genome-wide association study
KW - Sweet food consumption
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U2 - 10.1017/S0007114521000684
DO - 10.1017/S0007114521000684
M3 - Article
C2 - 33632354
AN - SCOPUS:85101795701
SN - 0007-1145
VL - 126
SP - 1843
EP - 1851
JO - British Journal of Nutrition
JF - British Journal of Nutrition
IS - 12
ER -