A genomic regulatory network for development

Eric H. Davidson, Jonathan P. Rast, Paola Oliveri, Andrew Ransick, Cristina Calestani, Chiou Hwa Yuh, Takuya Minokawa, Gabriele Amore, Veronica Hinman, César Arenas-Mena, Ochan Otim, C. Titus Brown, Carolina B. Livi, Pei Yun Lee, Roger Revilla, Alistair G. Rust, Zheng Jun Pan, Maria J. Schilstra, Peter J.C. Clarke, Maria I. ArnoneLee Rowen, R. Andrew Cameron, David R. McClay, Leroy Hood, Hamid Bolouri

Research output: Contribution to journalReview articlepeer-review

1225 Citations (Scopus)


Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory analysis, and molecular embryology. The network contains over 40 genes at present, and each node can be directly verified at the DNA sequence level by cis-regulatory analysis. its architecture reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time.

Original languageEnglish
Pages (from-to)1669-1678
Number of pages10
Issue number5560
Publication statusPublished - 2002 Mar 1


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