A genomic regulatory network for development

Eric H. Davidson; Jonathan P. Rast; Paola Oliveri; Andrew Ransick; Cristina Calestani; Chiou Hwa Yuh; Takuya Minokawa; Gabriele Amore; Veronica Hinman; César Arenas-Mena; Ochan Otim; C. Titus Brown; Carolina B. Livi; Pei Yun Lee; Roger Revilla; Alistair G. Rust; Zheng Jun Pan; Maria J. Schilstra; Peter J.C. Clarke; Maria I. Arnone; Lee Rowen; R. Andrew Cameron; David R. McClay; Leroy Hood; Hamid Bolouri

doi:10.1126/science.1069883

A genomic regulatory network for development

Eric H. Davidson, Jonathan P. Rast, Paola Oliveri, Andrew Ransick, Cristina Calestani, Chiou Hwa Yuh, Takuya Minokawa, Gabriele Amore, Veronica Hinman, César Arenas-Mena, Ochan Otim, C. Titus Brown, Carolina B. Livi, Pei Yun Lee, Roger Revilla, Alistair G. Rust, Zheng Jun Pan, Maria J. Schilstra, Peter J.C. Clarke, Maria I. ArnoneLee Rowen, R. Andrew Cameron, David R. McClay, Leroy Hood, Hamid Bolouri

LIF - Research Center for Marine Biology, Asamushi

California Institute of Technology

Research output: Contribution to journal › Review article › peer-review

1225 Citations (Scopus)

Abstract

Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory analysis, and molecular embryology. The network contains over 40 genes at present, and each node can be directly verified at the DNA sequence level by cis-regulatory analysis. its architecture reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time.

Original language	English
Pages (from-to)	1669-1678
Number of pages	10
Journal	Science
Volume	295
Issue number	5560
DOIs	https://doi.org/10.1126/science.1069883
Publication status	Published - 2002 Mar 1

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Davidson, E. H., Rast, J. P., Oliveri, P., Ransick, A., Calestani, C., Yuh, C. H., Minokawa, T., Amore, G., Hinman, V., Arenas-Mena, C., Otim, O., Brown, C. T., Livi, C. B., Lee, P. Y., Revilla, R., Rust, A. G., Pan, Z. J., Schilstra, M. J., Clarke, P. J. C., ... Bolouri, H. (2002). A genomic regulatory network for development. Science, 295(5560), 1669-1678. https://doi.org/10.1126/science.1069883

@article{46b232d06f7b4a4493fb550cc7e22ece,

title = "A genomic regulatory network for development",

abstract = "Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory analysis, and molecular embryology. The network contains over 40 genes at present, and each node can be directly verified at the DNA sequence level by cis-regulatory analysis. its architecture reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time.",

author = "Davidson, {Eric H.} and Rast, {Jonathan P.} and Paola Oliveri and Andrew Ransick and Cristina Calestani and Yuh, {Chiou Hwa} and Takuya Minokawa and Gabriele Amore and Veronica Hinman and C{\'e}sar Arenas-Mena and Ochan Otim and Brown, {C. Titus} and Livi, {Carolina B.} and Lee, {Pei Yun} and Roger Revilla and Rust, {Alistair G.} and Pan, {Zheng Jun} and Schilstra, {Maria J.} and Clarke, {Peter J.C.} and Arnone, {Maria I.} and Lee Rowen and Cameron, {R. Andrew} and McClay, {David R.} and Leroy Hood and Hamid Bolouri",

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doi = "10.1126/science.1069883",

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Davidson, EH, Rast, JP, Oliveri, P, Ransick, A, Calestani, C, Yuh, CH, Minokawa, T, Amore, G, Hinman, V, Arenas-Mena, C, Otim, O, Brown, CT, Livi, CB, Lee, PY, Revilla, R, Rust, AG, Pan, ZJ, Schilstra, MJ, Clarke, PJC, Arnone, MI, Rowen, L, Cameron, RA, McClay, DR, Hood, L & Bolouri, H 2002, 'A genomic regulatory network for development', Science, vol. 295, no. 5560, pp. 1669-1678. https://doi.org/10.1126/science.1069883

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T1 - A genomic regulatory network for development

AU - Davidson, Eric H.

AU - Rast, Jonathan P.

AU - Oliveri, Paola

AU - Ransick, Andrew

AU - Calestani, Cristina

AU - Yuh, Chiou Hwa

AU - Minokawa, Takuya

AU - Amore, Gabriele

AU - Hinman, Veronica

AU - Arenas-Mena, César

AU - Otim, Ochan

AU - Brown, C. Titus

AU - Livi, Carolina B.

AU - Lee, Pei Yun

AU - Revilla, Roger

AU - Rust, Alistair G.

AU - Pan, Zheng Jun

AU - Schilstra, Maria J.

AU - Clarke, Peter J.C.

AU - Arnone, Maria I.

AU - Rowen, Lee

AU - Cameron, R. Andrew

AU - McClay, David R.

AU - Hood, Leroy

AU - Bolouri, Hamid

PY - 2002/3/1

Y1 - 2002/3/1

N2 - Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory analysis, and molecular embryology. The network contains over 40 genes at present, and each node can be directly verified at the DNA sequence level by cis-regulatory analysis. its architecture reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time.

AB - Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory analysis, and molecular embryology. The network contains over 40 genes at present, and each node can be directly verified at the DNA sequence level by cis-regulatory analysis. its architecture reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time.

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DO - 10.1126/science.1069883

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SN - 0036-8075

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SP - 1669

EP - 1678

JO - Science

JF - Science

IS - 5560

ER -

A genomic regulatory network for development

Abstract

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