A label-free and sensitive fluorescent method for the detection of uracil-DNA glycosylase activity

Jing Tao, Panshu Song, Yusuke Sato, Seiichi Nishizawa, Norio Teramae, Aijun Tong, Yu Xiang

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

The activity of uracil-DNA glycosylase (UDG), an enzyme in the base excision repair, is detected at a high sensitivity by a DNA substrate containing only one uracil through a label-free fluorescent approach, which is also successfully applied for the measurement of UDG inhibitors.

Original languageEnglish
Pages (from-to)929-932
Number of pages4
JournalChemical Communications
Volume51
Issue number5
DOIs
Publication statusPublished - 2015 Jan 18

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