A large cell neuroendocrine carcinoma of the esophagus

Hiroshi Okamoto, Fumiyoshi Fujishima, Atsuko Kasajima, Go Miyata, Ko Onodera, Takashi Kamei, Daisuke Takeyama, Masashi Zuguchi, Susumu Satomi, Hironobu Sasano

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Neuroendocrine carcinomas generally have a poor prognosis, and large-cell types are rare. We report a case of large cell neuroendocrine carcinoma of the esophagus with long-term survival after surgical treatment. A 56-year-old man, previously hospitalized for dysphasia, was referred to our hospital with a diagnosis of neuroendocrine carcinoma of the esophagus. A localized polypoid tumor was detected in the middle thoracic esophagus, and on the basis of a diagnosis of T1bN0M0, Stage I neuroendocrine carcinoma, thoracoscopic esophagectomy was performed. Histopathological and immunohistochemical findings were cytokeratin AE1/AE3-positive, chromogranin A-positive, synaptophysin-positive, CD56-positive, p63-negative, Ki-67 (labeling index) 81.8%, and many mitotic figures. The final diagnosis was large cell neuroendocrine carcinoma, categorized as pT1b (SM1), ly1, v0, pN0, pStage I. The patient has been free from recurrence for 3 years and 5 months after surgery without any adjuvant therapy. We consider that this case of long-term survival after surgery alone was because the carcinoma was superficial without any lymph node metastasis.

Original languageEnglish
Pages (from-to)914-922
Number of pages9
JournalJapanese Journal of Gastroenterological Surgery
Issue number9
Publication statusPublished - 2012


  • Esophagus
  • Large cell type
  • Neuroendocrine carcinoma

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology


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