TY - JOUR
T1 - A mild inter- and intramolecular amination of aryl halides with a combination of CuI and CsOAc
AU - Kubo, Tetsuji
AU - Katoh, Chiharu
AU - Yamada, Ken
AU - Okano, Kentaro
AU - Tokuyama, Hidetoshi
AU - Fukuyama, Tohru
N1 - Funding Information:
This work was financially supported by a Grant-in-Aid (15109001, 17689003, 20390003) from the Ministry of Education, Culture, Sports, Science, and Technology, Japan, Kato Memorial Bioscience Foundation, Takeda Science Foundation, and JSPS (predoctoral fellowship for K.O.).
PY - 2008/12/1
Y1 - 2008/12/1
N2 - A unique combination of CuI and CsOAc was found to catalyze aryl amination under mild conditions. The reaction takes place at room temperature or at 90 °C with broad functional group compatibility. The intramolecular reaction was able to form five-, six-, and seven-membered rings with various protecting groups on the nitrogen atom. The scope of the intermolecular amination, as well as its applications to unsymmetrical N,N′-dialkylated phenylenediamines, was investigated.
AB - A unique combination of CuI and CsOAc was found to catalyze aryl amination under mild conditions. The reaction takes place at room temperature or at 90 °C with broad functional group compatibility. The intramolecular reaction was able to form five-, six-, and seven-membered rings with various protecting groups on the nitrogen atom. The scope of the intermolecular amination, as well as its applications to unsymmetrical N,N′-dialkylated phenylenediamines, was investigated.
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U2 - 10.1016/j.tet.2008.09.042
DO - 10.1016/j.tet.2008.09.042
M3 - Article
AN - SCOPUS:54549117892
SN - 0040-4020
VL - 64
SP - 11230
EP - 11236
JO - Tetrahedron
JF - Tetrahedron
IS - 49
ER -