@article{580bf59674bf4fa48140d5fa778fad32,
title = "A model system for studying superselective radiotherapy of lymph node metastasis in mice with swollen lymph nodes",
abstract = "Utilizing mice with swollen lymph nodes, we succeeded in irradiating individual metastatic lymph nodes through a hole in a lead shield. This system enabled us to increase the radiation dose to >8 Gy (the lethal dose for total-body irradiation) and evaluate both direct and abscopal antitumor effects.",
keywords = "Abscopal effect, Lymph node, Metastasis, Mouse model, Radiation",
author = "Ryohei Kikuchi and Ariunbuyan Sukhbaatar and Maya Sakamoto and Shiro Mori and Tetsuya Kodama",
note = "Funding Information: The present research was funded by JSPS KAKENHI with grants to TK (17H00865 and 17K20077) and MS (18H03544). The authors would like to thank the Biomedical Research Core of Tohoku University Graduate School of Medicine for invaluable technical support and T. Sato for excellent technical assistance. The present research was designed by RK, SM and TK. The experiments were carried out by RK and AS. The manuscript was written and figures created by RI, AS, SM and TK. All authors contributed to data interpretation and were equally involved in reviewing the final submitted manuscript. The authors declare that there are no competing financial interests. Publisher Copyright: {\textcopyright} 2019 The Authors",
year = "2020",
month = jan,
doi = "10.1016/j.ctro.2019.05.002",
language = "English",
volume = "20",
pages = "53--57",
journal = "Clinical and Translational Radiation Oncology",
issn = "2405-6308",
publisher = "Elsevier Ireland Ltd",
}