A new combination chemotherapy with Cis-diammine-glycolatoplatinum (Nedaplatin) and 5-fluorouracil for advanced esophageal cancers

Takashi Yoshioka, Makio Gamoh, Ryusaburo Shineha, Satoru Ishibashi, Hiroyuki Shibata, Takao Suzuki, Yasuko Murakawa, Syunsuke Kato, Hideki Shimodaira, Satoshi Kato, Chikashi Ishioka, Ryunosuke Kanamaru

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Objective: The efficacy of a new chemotherapeutic combination consisting of Cis-diammine-glycolatoplatinum (Nedaplatin), a derivative of cisplatin (CDDP), and 5-fluorouracil (5FU) was evaluated in patients with advanced esophageal carcinomas. Methods: Nedaplatin was administered at a dose of 80 or 100 mg/m2 with 500 ml of saline by slow drip infusion for 120 minutes on day 1.5FU at a dose of 350 or 500 mg/m2 was mixed with 1,000 ml of saline and administered by continuous infusion for 24 hours on days 1 to 5. Patients or Materials: This combination chemotherapy was tried in 17 patients with metastatic, recurrent, or bulky unresectable esophageal cancers. Of these, 15 evaluable patients received at least two courses of chemotherapy. Results: The response rates in assessable and all patients were 60% and 52.9%, respectively. Cases with lymph node and liver metastases, as well as primary lesions, showed excellent response to the therapy with positive response rates of 54.5% (6/11), 100% (5/5) and 58.4% (7/12), respectively. The median response duration was 7 (range 3 to 37+) months for patients who achieved a partial response. Adverse drug reactions were limited to three cases of grade 3 toxicity, including allergy, and decreased hemoglobin and platelets, which were well tolerated by the patients. Conclusion: The present study thus indicated the combination chemotherapy of Nedaplatin and 5FU to be safe and efficacious for advanced esophageal cancer. Further investigations are clearly warranted.

Original languageEnglish
Pages (from-to)844-848
Number of pages5
JournalInternal Medicine
Issue number11
Publication statusPublished - 1999 Nov


  • Antineoplastic agents
  • Cisplatin derivative
  • Drug effects
  • Squamous cell
  • Undifferentiated carcinoma


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