TY - JOUR
T1 - A new reactive nucleoside analogue for highly reactive and selective cross-linking reaction to cytidine under neutral conditions
AU - Nagatsugi, Fumi
AU - Tokuda, Natsuko
AU - Maeda, Minoru
AU - Sasaki, Shigeki
N1 - Funding Information:
This study was partially supported by a Grant-in-Aid for Scientific Research [Priority Area (A)(2), No. 13022250] from the Ministry of Education, Science, Sports, Science and Technology, Japan.
PY - 2001/10/8
Y1 - 2001/10/8
N2 - We have already demonstrated that the oligonucleotides DNA (ODNs) bearing a 2-amino-6-vinylpurine derivative (1) exhibited efficient interstrand cross-linking to cytidine selectively. In this study, a new reactive nucleoside analogue, 2-amino-6-(1-ethylsulfoxy)vinylpurine derivative (7), was designed based on a computational method to achieve high and selective alkylation with cytidine under neutral conditions. It has been demonstrated that the ODN (13) bearing 2-amino-6-(1-ethylsulfoxy)vinylpurine achieved highly selective and efficient cross-linking to cytidine under neutral conditions.
AB - We have already demonstrated that the oligonucleotides DNA (ODNs) bearing a 2-amino-6-vinylpurine derivative (1) exhibited efficient interstrand cross-linking to cytidine selectively. In this study, a new reactive nucleoside analogue, 2-amino-6-(1-ethylsulfoxy)vinylpurine derivative (7), was designed based on a computational method to achieve high and selective alkylation with cytidine under neutral conditions. It has been demonstrated that the ODN (13) bearing 2-amino-6-(1-ethylsulfoxy)vinylpurine achieved highly selective and efficient cross-linking to cytidine under neutral conditions.
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U2 - 10.1016/S0960-894X(01)00505-4
DO - 10.1016/S0960-894X(01)00505-4
M3 - Article
C2 - 11551753
AN - SCOPUS:0035829147
SN - 0960-894X
VL - 11
SP - 2577
EP - 2579
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 19
ER -