TY - JOUR
T1 - A novel chiral oxazolidine organocatalyst for the synthesis of an oseltamivir intermediate using a highly enantioselective Diels-Alder reaction of 1,2-dihydropyridine
AU - Nakano, Hiroto
AU - Osone, Kenichi
AU - Takeshita, Mitsuhiro
AU - Kwon, Eunsang
AU - Seki, Chigusa
AU - Matsuyama, Haruo
AU - Takano, Nobuhiro
AU - Kohari, Yoshihito
PY - 2010/7/14
Y1 - 2010/7/14
N2 - Enantioselective Diels-Alder reactions of 1,2-dihydropyridines with acroleins using a novel chiral oxazolidine organocatalyst afforded chiral isoquinuclidines that is an efficient synthetic intermediate of oseltamivir, with fairly good chemical yield and excellent enantioselectivity (90%, up to >99% ee).
AB - Enantioselective Diels-Alder reactions of 1,2-dihydropyridines with acroleins using a novel chiral oxazolidine organocatalyst afforded chiral isoquinuclidines that is an efficient synthetic intermediate of oseltamivir, with fairly good chemical yield and excellent enantioselectivity (90%, up to >99% ee).
UR - http://www.scopus.com/inward/record.url?scp=77953896626&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953896626&partnerID=8YFLogxK
U2 - 10.1039/c0cc00110d
DO - 10.1039/c0cc00110d
M3 - Article
C2 - 20502818
AN - SCOPUS:77953896626
SN - 1359-7345
VL - 46
SP - 4827
EP - 4829
JO - Chemical Communications
JF - Chemical Communications
IS - 26
ER -