A novel method of assessing carcinoma cell proliferation by biophoton emission

Motohiro Takeda, Yukina Tanno, Masaki Kobayashi, Masashi Usa, Noriaki Ohuchi, Susumu Satomi, Humio Inaba

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


Changes in the emission intensities of ultraweak biophoton emission during the cell proliferation of human carcinoma cell culture (TE9 cell line) were detected using a highly sensitive and low noise measurement apparatus coupled with a flow culture system. In the sampling period of 93 h, the biophoton emission intensity from the culture followed a similar course as that of the growth curve. Spectral analysis of the biophoton emission from the cell culture demonstrated a significant peak at around 530 nm. Our results suggest that the emission intensity mainly depends on the cell population and that this non-invasive technique has a potential role in cancer diagnosis.

Original languageEnglish
Pages (from-to)155-160
Number of pages6
JournalCancer Letters
Issue number1-2
Publication statusPublished - 1998 May 15


  • Cancer
  • Cell proliferation
  • TE9
  • Ultraweak biophoton emission
  • Ultraweak chemiluminescence

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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