A novel nuclear export inhibitor JBIR-02, a new piericidin discovered from Streptomyces sp. ML55

Jun Ya Ueda; Takushi Togashi; Susumu Matukura; Aya Nagai; Takuji Nakashima; Hisayuki Komaki; Kozue Anzai; Shigeaki Harayama; Takayuki Doi; Takashi Takahashi; Tohru Natsume; Yasutomo Kisu; Naoki Goshima; Nobuo Nomura; Motoki Takagi; Kazuo Shin-ya

doi:10.1038/ja.2007.59

A novel nuclear export inhibitor JBIR-02, a new piericidin discovered from Streptomyces sp. ML55

Jun Ya Ueda, Takushi Togashi, Susumu Matukura, Aya Nagai, Takuji Nakashima, Hisayuki Komaki, Kozue Anzai, Shigeaki Harayama, Takayuki Doi, Takashi Takahashi, Tohru Natsume, Yasutomo Kisu, Naoki Goshima, Nobuo Nomura, Motoki Takagi, Kazuo Shin-ya

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

A new member of the piericidin family, JBIR-02, was isolated from mycelium of Streptomyces sp. ML55 together with two known piericidin derivatives, piericidin A₁ and IT-143-B. The structure was determined on the basis of spectroscopic data. JBIR-02 inhibited nuclear export of β-arrestin in HeLa cells at the concentration of 20 μM.

Original language	English
Pages (from-to)	459-462
Number of pages	4
Journal	Journal of Antibiotics
Volume	60
Issue number	7
DOIs	https://doi.org/10.1038/ja.2007.59
Publication status	Published - 2007 Jul

Keywords

JBIR-02
Leptomycin
Nuclear transport
Piericidin
Streptomyces sp.

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10.1038/ja.2007.59

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Ueda, J. Y., Togashi, T., Matukura, S., Nagai, A., Nakashima, T., Komaki, H., Anzai, K., Harayama, S., Doi, T., Takahashi, T., Natsume, T., Kisu, Y., Goshima, N., Nomura, N., Takagi, M., & Shin-ya, K. (2007). A novel nuclear export inhibitor JBIR-02, a new piericidin discovered from Streptomyces sp. ML55. Journal of Antibiotics, 60(7), 459-462. https://doi.org/10.1038/ja.2007.59

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title = "A novel nuclear export inhibitor JBIR-02, a new piericidin discovered from Streptomyces sp. ML55",

abstract = "A new member of the piericidin family, JBIR-02, was isolated from mycelium of Streptomyces sp. ML55 together with two known piericidin derivatives, piericidin A1 and IT-143-B. The structure was determined on the basis of spectroscopic data. JBIR-02 inhibited nuclear export of β-arrestin in HeLa cells at the concentration of 20 μM.",

keywords = "JBIR-02, Leptomycin, Nuclear transport, Piericidin, Streptomyces sp.",

author = "Ueda, {Jun Ya} and Takushi Togashi and Susumu Matukura and Aya Nagai and Takuji Nakashima and Hisayuki Komaki and Kozue Anzai and Shigeaki Harayama and Takayuki Doi and Takashi Takahashi and Tohru Natsume and Yasutomo Kisu and Naoki Goshima and Nobuo Nomura and Motoki Takagi and Kazuo Shin-ya",

note = "Funding Information: Acknowledgements This work was supported by the grant from the New Energy and Industrial Technology Development Organization (NEDO) of Japan.",

year = "2007",

month = jul,

doi = "10.1038/ja.2007.59",

language = "English",

volume = "60",

pages = "459--462",

journal = "Journal of Antibiotics",

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Ueda, JY, Togashi, T, Matukura, S, Nagai, A, Nakashima, T, Komaki, H, Anzai, K, Harayama, S, Doi, T, Takahashi, T, Natsume, T, Kisu, Y, Goshima, N, Nomura, N, Takagi, M & Shin-ya, K 2007, 'A novel nuclear export inhibitor JBIR-02, a new piericidin discovered from Streptomyces sp. ML55', Journal of Antibiotics, vol. 60, no. 7, pp. 459-462. https://doi.org/10.1038/ja.2007.59

TY - JOUR

T1 - A novel nuclear export inhibitor JBIR-02, a new piericidin discovered from Streptomyces sp. ML55

AU - Ueda, Jun Ya

AU - Togashi, Takushi

AU - Matukura, Susumu

AU - Nagai, Aya

AU - Nakashima, Takuji

AU - Komaki, Hisayuki

AU - Anzai, Kozue

AU - Harayama, Shigeaki

AU - Doi, Takayuki

AU - Takahashi, Takashi

AU - Natsume, Tohru

AU - Kisu, Yasutomo

AU - Goshima, Naoki

AU - Nomura, Nobuo

AU - Takagi, Motoki

AU - Shin-ya, Kazuo

N1 - Funding Information: Acknowledgements This work was supported by the grant from the New Energy and Industrial Technology Development Organization (NEDO) of Japan.

PY - 2007/7

Y1 - 2007/7

N2 - A new member of the piericidin family, JBIR-02, was isolated from mycelium of Streptomyces sp. ML55 together with two known piericidin derivatives, piericidin A1 and IT-143-B. The structure was determined on the basis of spectroscopic data. JBIR-02 inhibited nuclear export of β-arrestin in HeLa cells at the concentration of 20 μM.

AB - A new member of the piericidin family, JBIR-02, was isolated from mycelium of Streptomyces sp. ML55 together with two known piericidin derivatives, piericidin A1 and IT-143-B. The structure was determined on the basis of spectroscopic data. JBIR-02 inhibited nuclear export of β-arrestin in HeLa cells at the concentration of 20 μM.

KW - JBIR-02

KW - Leptomycin

KW - Nuclear transport

KW - Piericidin

KW - Streptomyces sp.

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SN - 0021-8820

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JO - Journal of Antibiotics

JF - Journal of Antibiotics

IS - 7

ER -

A novel nuclear export inhibitor JBIR-02, a new piericidin discovered from Streptomyces sp. ML55

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