A new method for synthesizing α,β-acetylenic ketones by palladium-mediated coupling of thiol esters with 1-alkynes is described. The reaction could be applied to coupling of thiol esters bearing various functional groups, such as aromatic bromides, and ketones, with functionalized terminal acetylenes.
- 1-alkynyl ketones
- Sonogashira-type coupling reaction
- Thiol esters