TY - JOUR
T1 - A pediatric case of neuromyelitis optica spectrum disorder relapse with recurrent AQP4-IgG positivity
AU - Kawashima, Aritomo
AU - Fukuyo, Naomi
AU - Abe, Yu
AU - Takezawa, Yusuke
AU - Uematsu, Mitsugu
AU - Numata-Uematsu, Yurika
AU - Takahashi, Toshiyuki
AU - Nishiyama, Shuhei
AU - Nakashima, Ichiro
AU - Kure, Shigeo
N1 - Publisher Copyright:
© 2021 Japanese Society of Child Neurology. All rights reserved.
PY - 2021
Y1 - 2021
N2 - We describe the clinical course of a patient with neuromyelitis optica spectrum disorder who showed reconversion (negative to positive) of AQP4-IgG upon clinical relapse after tapering prednisolone. Because of side effects, prednisolone could not be administered as maintenance therapy to prevent recurrence. Combination therapy with tacrolimus maintained the AQP4-IgG negative state while tapering the prednisolone. Prednisolone should be tapered carefully and the addition of an immunosuppressant should be considered.
AB - We describe the clinical course of a patient with neuromyelitis optica spectrum disorder who showed reconversion (negative to positive) of AQP4-IgG upon clinical relapse after tapering prednisolone. Because of side effects, prednisolone could not be administered as maintenance therapy to prevent recurrence. Combination therapy with tacrolimus maintained the AQP4-IgG negative state while tapering the prednisolone. Prednisolone should be tapered carefully and the addition of an immunosuppressant should be considered.
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U2 - 10.11251/ojjscn.53.66
DO - 10.11251/ojjscn.53.66
M3 - Article
AN - SCOPUS:85105819146
SN - 0029-0831
VL - 53
SP - 66
EP - 68
JO - No To Hattatsu
JF - No To Hattatsu
IS - 1
ER -