A pediatric case of osteosarcoma and tuberous sclerosis complex with a novel germline mutation in the TSC2 gene and a somatic mutation in the TP53 gene

Kaoru Kuroda; Kunihiko Moriya; Tomohiro Nakano; Ryoko Saito; Daichi Sato; Saori Katayama; Hidetaka Niizuma; Munenori Watanuki; Mitsugu Uematsu; Yoji Sasahara; Shigeo Kure

doi:10.1002/pbc.28960

A pediatric case of osteosarcoma and tuberous sclerosis complex with a novel germline mutation in the TSC2 gene and a somatic mutation in the TP53 gene

Kaoru Kuroda, Kunihiko Moriya, Tomohiro Nakano, Ryoko Saito, Daichi Sato, Saori Katayama, Hidetaka Niizuma, Munenori Watanuki, Mitsugu Uematsu, Yoji Sasahara, Shigeo Kure

Tohoku University

Research output: Contribution to journal › Letter › peer-review

1 Citation (Scopus)

Original language	English
Article number	e28960
Journal	Pediatric Blood and Cancer
Volume	68
Issue number	6
DOIs	https://doi.org/10.1002/pbc.28960
Publication status	Published - 2021 Jun

Keywords

mTOR inhibitor
osteosarcoma
TP53
TSC2
tuberous sclerosis complex

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10.1002/pbc.28960

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Kuroda, K., Moriya, K., Nakano, T., Saito, R., Sato, D., Katayama, S., Niizuma, H., Watanuki, M., Uematsu, M., Sasahara, Y., & Kure, S. (2021). A pediatric case of osteosarcoma and tuberous sclerosis complex with a novel germline mutation in the TSC2 gene and a somatic mutation in the TP53 gene. Pediatric Blood and Cancer, 68(6), Article e28960. https://doi.org/10.1002/pbc.28960

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title = "A pediatric case of osteosarcoma and tuberous sclerosis complex with a novel germline mutation in the TSC2 gene and a somatic mutation in the TP53 gene",

keywords = "mTOR inhibitor, osteosarcoma, TP53, TSC2, tuberous sclerosis complex",

author = "Kaoru Kuroda and Kunihiko Moriya and Tomohiro Nakano and Ryoko Saito and Daichi Sato and Saori Katayama and Hidetaka Niizuma and Munenori Watanuki and Mitsugu Uematsu and Yoji Sasahara and Shigeo Kure",

note = "Funding Information: We thank the patient and her parents for participating in this study. We thank all of our colleagues in the Department of Pediatrics who have been involved in the patient's care and research. Kunihiko Moriya was supported by grant from the Japanese Ministry of Health, Labour and Welfare of Japan (Grant Number 19K23819).",

year = "2021",

month = jun,

doi = "10.1002/pbc.28960",

language = "English",

volume = "68",

journal = "Pediatric Blood and Cancer",

issn = "1545-5009",

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Kuroda, K, Moriya, K, Nakano, T, Saito, R, Sato, D, Katayama, S , Niizuma, H, Watanuki, M, Uematsu, M , Sasahara, Y & Kure, S 2021, 'A pediatric case of osteosarcoma and tuberous sclerosis complex with a novel germline mutation in the TSC2 gene and a somatic mutation in the TP53 gene', Pediatric Blood and Cancer, vol. 68, no. 6, e28960. https://doi.org/10.1002/pbc.28960

TY - JOUR

T1 - A pediatric case of osteosarcoma and tuberous sclerosis complex with a novel germline mutation in the TSC2 gene and a somatic mutation in the TP53 gene

AU - Kuroda, Kaoru

AU - Moriya, Kunihiko

AU - Nakano, Tomohiro

AU - Saito, Ryoko

AU - Sato, Daichi

AU - Katayama, Saori

AU - Niizuma, Hidetaka

AU - Watanuki, Munenori

AU - Uematsu, Mitsugu

AU - Sasahara, Yoji

AU - Kure, Shigeo

N1 - Funding Information: We thank the patient and her parents for participating in this study. We thank all of our colleagues in the Department of Pediatrics who have been involved in the patient's care and research. Kunihiko Moriya was supported by grant from the Japanese Ministry of Health, Labour and Welfare of Japan (Grant Number 19K23819).

PY - 2021/6

Y1 - 2021/6

KW - mTOR inhibitor

KW - osteosarcoma

KW - TP53

KW - TSC2

KW - tuberous sclerosis complex

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U2 - 10.1002/pbc.28960

DO - 10.1002/pbc.28960

M3 - Letter

C2 - 33694273

AN - SCOPUS:85102287104

SN - 1545-5009

VL - 68

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

IS - 6

M1 - e28960

ER -

A pediatric case of osteosarcoma and tuberous sclerosis complex with a novel germline mutation in the TSC2 gene and a somatic mutation in the TP53 gene

Keywords

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