A physiological model for cerebral oxygen delivery and consumption and effective oxygen diffusibility evaluated by PET

Takuya Hayashi; Nobuyuki Kudomi; Noboru Teramoto; Hiroshi Watabe; Jun Ichiro Enmi; Kyeong Min Kim; Hidehiro Iida

doi:10.1016/j.ics.2004.04.043

A physiological model for cerebral oxygen delivery and consumption and effective oxygen diffusibility evaluated by PET

Takuya Hayashi, Nobuyuki Kudomi, Noboru Teramoto, Hiroshi Watabe, Jun Ichiro Enmi, Kyeong Min Kim, Hidehiro Iida

Cyclotron and Radioisotope Center (CYRIC)

National Cerebral and Cardiovascular Center

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The coupling of cerebral blood flow (CBF) and metabolic rate of oxygen (CMRO₂) during physiological and pathological conditions remains a subject of debate. We have developed a physiological model for oxygen delivery and metabolism, which allows the estimation of net oxygen diffusibility at the capillary level, termed “effective oxygen diffusibility (EOD).” The results of PET in monkeys showed dynamic changes in EOD in response to changes in oxygen delivery and consumption. EOD is defined as capillary volume and permeability product, but its change mainly reflects the pericapillary oxygen gradient as long as capillary architecture is preserved. EOD may have sufficient predictability to represent the tissue oxygen demand and application of the model to PET data. In the future, EOD may give us further insight to understand the physiological regulatory system for oxygen demand in the brain.

Original language	English
Pages (from-to)	228-237
Number of pages	10
Journal	International Congress Series
Volume	1265
Issue number	C
DOIs	https://doi.org/10.1016/j.ics.2004.04.043
Publication status	Published - 2004 Aug 1

Keywords

Capillary
Cerebral blood flow
Oxygen diffusibility
Oxygen metabolism

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10.1016/j.ics.2004.04.043

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title = "A physiological model for cerebral oxygen delivery and consumption and effective oxygen diffusibility evaluated by PET",

abstract = "The coupling of cerebral blood flow (CBF) and metabolic rate of oxygen (CMRO2) during physiological and pathological conditions remains a subject of debate. We have developed a physiological model for oxygen delivery and metabolism, which allows the estimation of net oxygen diffusibility at the capillary level, termed “effective oxygen diffusibility (EOD).” The results of PET in monkeys showed dynamic changes in EOD in response to changes in oxygen delivery and consumption. EOD is defined as capillary volume and permeability product, but its change mainly reflects the pericapillary oxygen gradient as long as capillary architecture is preserved. EOD may have sufficient predictability to represent the tissue oxygen demand and application of the model to PET data. In the future, EOD may give us further insight to understand the physiological regulatory system for oxygen demand in the brain.",

keywords = "Capillary, Cerebral blood flow, Oxygen diffusibility, Oxygen metabolism",

author = "Takuya Hayashi and Nobuyuki Kudomi and Noboru Teramoto and Hiroshi Watabe and Enmi, {Jun Ichiro} and Kim, {Kyeong Min} and Hidehiro Iida",

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T1 - A physiological model for cerebral oxygen delivery and consumption and effective oxygen diffusibility evaluated by PET

AU - Hayashi, Takuya

AU - Kudomi, Nobuyuki

AU - Teramoto, Noboru

AU - Watabe, Hiroshi

AU - Enmi, Jun Ichiro

AU - Kim, Kyeong Min

AU - Iida, Hidehiro

PY - 2004/8/1

Y1 - 2004/8/1

N2 - The coupling of cerebral blood flow (CBF) and metabolic rate of oxygen (CMRO2) during physiological and pathological conditions remains a subject of debate. We have developed a physiological model for oxygen delivery and metabolism, which allows the estimation of net oxygen diffusibility at the capillary level, termed “effective oxygen diffusibility (EOD).” The results of PET in monkeys showed dynamic changes in EOD in response to changes in oxygen delivery and consumption. EOD is defined as capillary volume and permeability product, but its change mainly reflects the pericapillary oxygen gradient as long as capillary architecture is preserved. EOD may have sufficient predictability to represent the tissue oxygen demand and application of the model to PET data. In the future, EOD may give us further insight to understand the physiological regulatory system for oxygen demand in the brain.

AB - The coupling of cerebral blood flow (CBF) and metabolic rate of oxygen (CMRO2) during physiological and pathological conditions remains a subject of debate. We have developed a physiological model for oxygen delivery and metabolism, which allows the estimation of net oxygen diffusibility at the capillary level, termed “effective oxygen diffusibility (EOD).” The results of PET in monkeys showed dynamic changes in EOD in response to changes in oxygen delivery and consumption. EOD is defined as capillary volume and permeability product, but its change mainly reflects the pericapillary oxygen gradient as long as capillary architecture is preserved. EOD may have sufficient predictability to represent the tissue oxygen demand and application of the model to PET data. In the future, EOD may give us further insight to understand the physiological regulatory system for oxygen demand in the brain.

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KW - Cerebral blood flow

KW - Oxygen diffusibility

KW - Oxygen metabolism

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A physiological model for cerebral oxygen delivery and consumption and effective oxygen diffusibility evaluated by PET

Abstract

Keywords

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