A platform for controlled dual-drug elivery to the retina: Protective effects against light-Induced retinal damage in rats

Nobuhiro Nagai; Hirokazu Kaji; Hideyuki Onami; Yuki Katsukura; Yumi Ishikawa; Zhaleh Kashkouli Nezhad; Kaori Sampei; Satoru Iwata; Shuntaro Ito; Matsuhiko Nishizawa; Toru Nakazawa; Noriko Osumi; Yukihiko Mashima; Toshiaki Abe

doi:10.1002/adhm.201400114

A platform for controlled dual-drug elivery to the retina: Protective effects against light-Induced retinal damage in rats

Nobuhiro Nagai, Hirokazu Kaji, Hideyuki Onami, Yuki Katsukura, Yumi Ishikawa, Zhaleh Kashkouli Nezhad, Kaori Sampei, Satoru Iwata, Shuntaro Ito, Matsuhiko Nishizawa, Toru Nakazawa, Noriko Osumi, Yukihiko Mashima, Toshiaki Abe

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Controlled transscleral co-delivery of two drugs, edaravone (EDV) and unoprostone (UNO), using a platform that comprises a microfabricated reservoir, controlled-release cover, and drug formulations, which are made of photopolymerized poly(ethyleneglycol) dimethacrylates, shows synergistic retinal neuroprotection against light injury in rats when compared with single-drug-loaded devices. The device would offer a safer therapeutic method than intravitreal injections for retinal disease treatments.

Original language	English
Pages (from-to)	1555-1560
Number of pages	6
Journal	Advanced healthcare materials
Volume	3
Issue number	10
DOIs	https://doi.org/10.1002/adhm.201400114
Publication status	Published - 2014 Oct 1

Keywords

Edaravone
Poly(ethyleneglycol) dimethacrylate
Retina
Transscleral drug delivery
Unoprostone

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10.1002/adhm.201400114

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Nagai, N., Kaji, H., Onami, H., Katsukura, Y., Ishikawa, Y., Nezhad, Z. K., Sampei, K., Iwata, S., Ito, S., Nishizawa, M., Nakazawa, T., Osumi, N., Mashima, Y., & Abe, T. (2014). A platform for controlled dual-drug elivery to the retina: Protective effects against light-Induced retinal damage in rats. Advanced healthcare materials, 3(10), 1555-1560. https://doi.org/10.1002/adhm.201400114

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abstract = "Controlled transscleral co-delivery of two drugs, edaravone (EDV) and unoprostone (UNO), using a platform that comprises a microfabricated reservoir, controlled-release cover, and drug formulations, which are made of photopolymerized poly(ethyleneglycol) dimethacrylates, shows synergistic retinal neuroprotection against light injury in rats when compared with single-drug-loaded devices. The device would offer a safer therapeutic method than intravitreal injections for retinal disease treatments.",

keywords = "Edaravone, Poly(ethyleneglycol) dimethacrylate, Retina, Transscleral drug delivery, Unoprostone",

author = "Nobuhiro Nagai and Hirokazu Kaji and Hideyuki Onami and Yuki Katsukura and Yumi Ishikawa and Nezhad, {Zhaleh Kashkouli} and Kaori Sampei and Satoru Iwata and Shuntaro Ito and Matsuhiko Nishizawa and Toru Nakazawa and Noriko Osumi and Yukihiko Mashima and Toshiaki Abe",

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Nagai, N, Kaji, H, Onami, H, Katsukura, Y, Ishikawa, Y, Nezhad, ZK, Sampei, K, Iwata, S, Ito, S, Nishizawa, M , Nakazawa, T , Osumi, N, Mashima, Y & Abe, T 2014, 'A platform for controlled dual-drug elivery to the retina: Protective effects against light-Induced retinal damage in rats', Advanced healthcare materials, vol. 3, no. 10, pp. 1555-1560. https://doi.org/10.1002/adhm.201400114

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AU - Nagai, Nobuhiro

AU - Kaji, Hirokazu

AU - Onami, Hideyuki

AU - Katsukura, Yuki

AU - Ishikawa, Yumi

AU - Nezhad, Zhaleh Kashkouli

AU - Sampei, Kaori

AU - Iwata, Satoru

AU - Ito, Shuntaro

AU - Nishizawa, Matsuhiko

AU - Nakazawa, Toru

AU - Osumi, Noriko

AU - Mashima, Yukihiko

AU - Abe, Toshiaki

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KW - Poly(ethyleneglycol) dimethacrylate

KW - Retina

KW - Transscleral drug delivery

KW - Unoprostone

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A platform for controlled dual-drug elivery to the retina: Protective effects against light-Induced retinal damage in rats

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