A porphyrin tetramer for a positive homotropic allosteric recognition system: Efficient binding information transduction through butadiynyl axis rotation

Yohei Kubo; Masato Ikeda; Atsushi Sugasaki; Masayuki Takeuchi; Seiji Shinkai

doi:10.1016/S0040-4039(01)01546-5

A porphyrin tetramer for a positive homotropic allosteric recognition system: Efficient binding information transduction through butadiynyl axis rotation

Yohei Kubo, Masato Ikeda, Atsushi Sugasaki, Masayuki Takeuchi, Seiji Shinkai

Research output: Contribution to journal › Article › peer-review

Abstract

A porphyrin tetramer 1 was newly designed and synthesized to construct a novel allosteric guest-binding system. Compound 1 has a butadiynyl rotational axis, which is expected to act as a guest-binding information transducer. In chloroform, 1 can bind bidentate amines, such as 1,3-di(4-piperidyl)propane (DPP), in an allosteric manner to produce a 1:2 1/diamine complex with a Hill coefficient of 1.9.

Original language	English
Pages (from-to)	7435-7438
Number of pages	4
Journal	Tetrahedron Letters
Volume	42
Issue number	42
DOIs	https://doi.org/10.1016/S0040-4039(01)01546-5
Publication status	Published - 2001 Oct 15
Externally published	Yes

Keywords

Allosterism
Cooperativity
Molecular recognition
Porphyrin
Rotational axis

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(01)01546-5

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abstract = "A porphyrin tetramer 1 was newly designed and synthesized to construct a novel allosteric guest-binding system. Compound 1 has a butadiynyl rotational axis, which is expected to act as a guest-binding information transducer. In chloroform, 1 can bind bidentate amines, such as 1,3-di(4-piperidyl)propane (DPP), in an allosteric manner to produce a 1:2 1/diamine complex with a Hill coefficient of 1.9.",

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author = "Yohei Kubo and Masato Ikeda and Atsushi Sugasaki and Masayuki Takeuchi and Seiji Shinkai",

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T2 - Efficient binding information transduction through butadiynyl axis rotation

AU - Kubo, Yohei

AU - Ikeda, Masato

AU - Sugasaki, Atsushi

AU - Takeuchi, Masayuki

AU - Shinkai, Seiji

PY - 2001/10/15

Y1 - 2001/10/15

N2 - A porphyrin tetramer 1 was newly designed and synthesized to construct a novel allosteric guest-binding system. Compound 1 has a butadiynyl rotational axis, which is expected to act as a guest-binding information transducer. In chloroform, 1 can bind bidentate amines, such as 1,3-di(4-piperidyl)propane (DPP), in an allosteric manner to produce a 1:2 1/diamine complex with a Hill coefficient of 1.9.

AB - A porphyrin tetramer 1 was newly designed and synthesized to construct a novel allosteric guest-binding system. Compound 1 has a butadiynyl rotational axis, which is expected to act as a guest-binding information transducer. In chloroform, 1 can bind bidentate amines, such as 1,3-di(4-piperidyl)propane (DPP), in an allosteric manner to produce a 1:2 1/diamine complex with a Hill coefficient of 1.9.

KW - Allosterism

KW - Cooperativity

KW - Molecular recognition

KW - Porphyrin

KW - Rotational axis

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ER -

A porphyrin tetramer for a positive homotropic allosteric recognition system: Efficient binding information transduction through butadiynyl axis rotation

Abstract

Keywords

ASJC Scopus subject areas

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