5-Substituted 1 H -tetrazoles were effectively synthesized from aldoximes and diphenyl phosphorazidate (DPPA) under reflux conditions in xylenes. Various aldoximes underwent the cycloaddition reaction to afford the corresponding 5-substituted 1 H -tetrazoles in short reaction times and in good yields. Chiral aldoximes derived from amino acids also gave aminotetrazoles with almost no racemization.
|Number of pages||8|
|Publication status||Published - 2018 Mar 15|
- diphenyl phosphorazidate
ASJC Scopus subject areas
- Organic Chemistry