A primary Barrett’s adenocarcinoma with a squamous cell carcinoma component

Akio Takeuchi; Waku Hatta; Tomoyuki Koike; Masahiro Saito; Xiaoyi Jin; Kiyotaka Asanuma; Kaname Uno; Naoki Asano; Akira Imatani; Fumiyoshi Fujishima; Atsushi Masamune

doi:10.2169/internalmedicine.2722-19

A primary Barrett’s adenocarcinoma with a squamous cell carcinoma component

Akio Takeuchi, Waku Hatta, Tomoyuki Koike, Masahiro Saito, Xiaoyi Jin, Kiyotaka Asanuma, Kaname Uno, Naoki Asano, Akira Imatani, Fumiyoshi Fujishima, Atsushi Masamune

Tohoku University

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The present report describes an extremely rare case of Barrett’s adenocarcinoma (BAC) with a squamous cell carcinoma (SCC) component. A 55-year-old man was diagnosed with esophageal adenocarcinoma on Barrett’s esophagus. The patient underwent endoscopic submucosal dissection, but the pathology revealed deep submucosal invasive, moderately differentiated tubular adenocarcinoma and focal SCC with vascular invasion. In addition, morphological transition between adenocarcinoma and SCC components was confirmed. The patient underwent additional surgery, which revealed lymph node metastasis, and then received S-1 adjuvant chemotherapy. Based on the pathological findings, the transdifferentiation process may have a role in the histogenesis of this tumor.

Original language	English
Pages (from-to)	2467-2472
Number of pages	6
Journal	Internal Medicine
Volume	58
Issue number	17
DOIs	https://doi.org/10.2169/internalmedicine.2722-19
Publication status	Published - 2019

Keywords

Barrett’s adenocarcinoma
Morphological transition
Squamous cell carcinoma component

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10.2169/internalmedicine.2722-19

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title = "A primary Barrett{\textquoteright}s adenocarcinoma with a squamous cell carcinoma component",

abstract = "The present report describes an extremely rare case of Barrett{\textquoteright}s adenocarcinoma (BAC) with a squamous cell carcinoma (SCC) component. A 55-year-old man was diagnosed with esophageal adenocarcinoma on Barrett{\textquoteright}s esophagus. The patient underwent endoscopic submucosal dissection, but the pathology revealed deep submucosal invasive, moderately differentiated tubular adenocarcinoma and focal SCC with vascular invasion. In addition, morphological transition between adenocarcinoma and SCC components was confirmed. The patient underwent additional surgery, which revealed lymph node metastasis, and then received S-1 adjuvant chemotherapy. Based on the pathological findings, the transdifferentiation process may have a role in the histogenesis of this tumor.",

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T1 - A primary Barrett’s adenocarcinoma with a squamous cell carcinoma component

AU - Takeuchi, Akio

AU - Hatta, Waku

AU - Koike, Tomoyuki

AU - Saito, Masahiro

AU - Jin, Xiaoyi

AU - Asanuma, Kiyotaka

AU - Uno, Kaname

AU - Asano, Naoki

AU - Imatani, Akira

AU - Fujishima, Fumiyoshi

AU - Masamune, Atsushi

PY - 2019

Y1 - 2019

N2 - The present report describes an extremely rare case of Barrett’s adenocarcinoma (BAC) with a squamous cell carcinoma (SCC) component. A 55-year-old man was diagnosed with esophageal adenocarcinoma on Barrett’s esophagus. The patient underwent endoscopic submucosal dissection, but the pathology revealed deep submucosal invasive, moderately differentiated tubular adenocarcinoma and focal SCC with vascular invasion. In addition, morphological transition between adenocarcinoma and SCC components was confirmed. The patient underwent additional surgery, which revealed lymph node metastasis, and then received S-1 adjuvant chemotherapy. Based on the pathological findings, the transdifferentiation process may have a role in the histogenesis of this tumor.

AB - The present report describes an extremely rare case of Barrett’s adenocarcinoma (BAC) with a squamous cell carcinoma (SCC) component. A 55-year-old man was diagnosed with esophageal adenocarcinoma on Barrett’s esophagus. The patient underwent endoscopic submucosal dissection, but the pathology revealed deep submucosal invasive, moderately differentiated tubular adenocarcinoma and focal SCC with vascular invasion. In addition, morphological transition between adenocarcinoma and SCC components was confirmed. The patient underwent additional surgery, which revealed lymph node metastasis, and then received S-1 adjuvant chemotherapy. Based on the pathological findings, the transdifferentiation process may have a role in the histogenesis of this tumor.

KW - Barrett’s adenocarcinoma

KW - Morphological transition

KW - Squamous cell carcinoma component

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A primary Barrett’s adenocarcinoma with a squamous cell carcinoma component

Abstract

Keywords

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