A Rat Model for Monitoring Homograft Rejection of the Lung

Takashi Kondo, Fumihiro Shionozaki, Shigefumi Fujimura, Atsushi Yamauchi, Masashi Handa, Takeshi Okabe, Ryo Saito, Takashi Ichinose, Yuji Shiraishi, Tasuku Nakada

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


A new surgical procedure was devised for the experimental homograft of the lung. The pulmonary artery and vein and bronchus were anastomosed under the operation microscope using interrupted sutures in group W (30 outbred Wistar rats) and continuous sutures in group F (7 inbred F344/Ducrj Rats). Mean ischemia time during the operation was 95.3±10.3 min in the group W and 55.6 ± 5.8 in group F. Eight out of 30 rats (27%) of group W and all rats of group F survived more than 24 hr after the surgery. Pulmonary functions of grafted lungs were evaluated by serial x-rays and the perfusion ratio was 27.4±11.6% (mean± S.D.) in group W and 25.4± 7.7% in group F. A patent opening of the hilar anastomosis in these rats was confirmed at autopsy. This model with continuous suture would be useful for the rat lung transplantation.

Original languageEnglish
Pages (from-to)323-328
Number of pages6
Journalthe tohoku journal of experimental medicine
Issue number3
Publication statusPublished - 1986


  • microsurgery
  • rat lung transplantation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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